Expression of Tbx2 and Tbx3 in the developing hypothalamic–pituitary axis
Abstract
TBX2 and TBX3 are transcription factors that belong to the T-box family, members of which play important roles during mammalian embryogenesis. Mutations in T-box genes have been linked to several human genetic disorders and increasing evidence suggests that Tbx2 and Tbx3 may play a key role in cancer. The primary functions of Tbx2 and Tbx3 remain poorly defined, mainly because of their widespread expression in several tissues and their multiple potential roles in morphogenesis, organogenesis and cell-fate commitment. Here, we describe in detail the expression of Tbx2 and Tbx3 in the developing hypothalamic-pituitary axis. Localized transcripts can be detected during the early stages of pituitary commitment. Expression of Tbx2 is restricted to the infundibular region of the ventral diencephalon (VD) at all ages examined, whereas Tbx3 can be detected in both the VD and Rathke's pouch, the precursor of the anterior pituitary. Outside the developing hypophyseal organ novel sites of Tbx3 and Tbx2 expression include migrating branchiomotor (BM) and visceromotor (VM) neurons in the hindbrain, neuroepithelial cells of the developing tongue (Tbx3) as well as the developing blood vessel network (Tbx2).
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Tbx3 expression within lung mesenchyme at E14.5 is markedly abolished in Usp15null mutants.
“Tbx3 expression within lung mesenchyme at E14.5 was also markedly abolished from Usp15null mutants49,50 (Fig. 6c).”
From Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis (2024) · cites this paper as [49]
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Renard, C.-A., Labalette, C., Armengol, C., Cougot, D., Wei, Y., Cairo, S., Pineau, P., Neuveut, C., de Reyniès, A., Dejean, A., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2344 · Cited by 157 · see citing works
Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling
Suzuki, T., Takeuchi, J., Koshiba-Takeuchi, K., & Ogura, T. (2004) · Developmental Cell · doi:10.1016/s1534-5807(03)00401-5 · Cited by 148 · see citing works
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The roles and regulation of TBX3 in development and disease
Khan, S. F., Damerell, V., Omar, R., Du Toit, M., Khan, M., Maranyane, H. M., Mlaza, M., Bleloch, J., Bellis, C., Sahm, B. D. B., et al. (2020) · Gene · doi:10.1016/j.gene.2019.144223 · Cited by 99 · see citing works
“During mouse embryonic development, Tbx3 is expressed in the inner cell mass of the blastocyst, in the extraembryonic mesoderm during gastrulation, and in the developing heart, limbs, musculoskeletal, mammary glands, nervous system, skin, eye, liver, pancreas, lungs, pituitary glands and genitalia (Chapman et al., 199…”
BackgroundFunctional identity of hypothalamic melanocortin neurons depends on Tbx3
Quarta, C., Fisette, A., Xu, Y., Colldén, G., Legutko, B., Tseng, Y.-T., Reim, A., Wierer, M., De Rosa, M. C., Klaus, V., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0028-1 · Cited by 54 · see citing works
Zhang, Z., Wu, Y., Fu, J., Yu, X., Su, Y., Jia, S., Cheng, H., Shen, Y., He, X., Ren, K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48173-9 · Cited by 14 · see citing works
“5 was also markedly abolished from Usp15 null mutants 49,50 (Fig.”
Background
- Authors
- Pontecorvi, M., Goding, C. R., Richardson, W. D., & Kessaris, N.
- Affiliations
- University College London (GB)
- Marie Curie (GB)
- Corresponding author
- Pontecorvi, Marco
- Venue
- Gene Expression Patterns
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 8
- Issue
- 6
- Pages
- 411-417
- ISSN
- 1567-133X (ISSN-L)
- OpenAlex
- W1988843027
- Cited by
- 40
- References
- 2
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2013: 3 · 2012: 1
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gene Expression Patterns (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- TBX2, TBX3, T-box transcription factor, hypothalamic-pituitary axis, pituitary development, infundibulum, ventral diencephalon, Rathke's pouch, anterior pituitary, blood vessel development, embryonic gene expression
- MeSH terms
- Animals, Hypothalamo-Hypophyseal System, RNA, Messenger, In Situ Hybridization, Gene Expression Regulation, Developmental, T-Box Domain Proteins, Mice
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