Geography of Genetics and Genomics Research Funding in Africa
Open accessAbstract
An estimated U.S. $300 billion is spent each year on medical research. What proportion of this goes to genomics and genetics research in Africa? Until recently, this type of question was nearly impossible to answer. The World RePORT database, sponsored by the Heads of International Research Organizations (HIRO) and managed by the National Institutes of Health (NIH), provides a first attempt at answering questions on the distribution of research funding by geography and research organization. In this journal issue on the Human Heredity and Health in Africa (H3Africa), we explore the geography of biomedical research funding in the genomics field with special emphasis on Africa. Using World RePORT, we identified 185 research projects in genetics and genomics in Africa in 2015 with total funding exceeding U.S. $216 million. These numbers are likely incomplete and more efforts at collating data from funder organizations is needed. A comprehensive snapshot of funders' portfolios will be invaluable to research investigators and policy makers in the identification of research gaps and analysis of allocation priorities to facilitate evidence-based decision-making for public-research-funding organizations.
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The H3Africa Initiative has increased genomics research capacity in Africa through more than $216 million in funding from the NIH (USA) and Wellcome Trust (UK) for genetics research led by African investigators.
“The most notable investment here comes from the Human Heredity and Health in Africa (H3Africa) Initiative, increasing genomics research capacity in Africa through more than $216 million in funding from the NIH (USA) and Wellcome Trust (UK) for genetics research led by African investigators55,74.”
From Clinical use of current polygenic risk scores may exacerbate health disparities (2019) · cites this paper as [74]
The Introduction says substantial NIH and Wellcome Trust investment in H3Africa gave genetics and genomics research in sub-Saharan Africa momentum. But the Results and Summary and Conclusions identify approximately $216 million as 2015 funding for 185 genetics and genomics projects across Africa, not funding for H3Africa alone; the paper also does not establish that those projects were led by African investigators. (LLM, conf=0.89)
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Cites
The Anatomy of Medical Research: US and International Comparisons
Moses, H., Matheson, D. H. M., Cairns-Smith, S., George, B. P., Palisch, C., & Dorsey, E. R. (2015) · JAMA · doi:10.1001/jama.2014.15939 · Cited by 446 · see citing works
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Clinical use of current polygenic risk scores may exacerbate health disparities
Martin, A. R., Kanai, M., Kamatani, Y., Okada, Y., Neale, B. M., & Daly, M. J. (2019) · Nature Genetics · doi:10.1038/s41588-019-0379-x · Cited by 2,831 · see citing works
Current clinical use of polygenic scores will risk exacerbating health disparities
Martin, A. R., Kanai, M., Kamatani, Y., Okada, Y., Neale, B. M., & Daly, M. J. (2018) · doi:10.1101/441261 · Cited by 2,813 · see citing works
- Authors
- Coles, E., & Mensah, G. A.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Mensah, George A.
- ORCID
- Mensah, George A.
- Venue
- Global Heart
- Publisher
- Ubiquity Press, Ltd.
- Published
- 2017-06-01
- Volume
- 12
- Issue
- 2
- Pages
- 173
- ISSN
- 2211-8160 (ISSN-L)
- 2211-8179
- PMC
- PMC5659356
- OpenAlex
- W2752471688
- Cited by
- 34
- References
- 1
- Citations by year
- 2025: 1 · 2024: 24 · 2023: 1 · 2022: 2 · 2020: 2 · 2019: 2 · 2018: 2
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Global Heart (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 HL999999)
- Fogarty International Center
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health and Medical Research Impacts
- Social Sciences › Decision Sciences › Information Systems and Management › Research, Science, and Academia
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Biotechnology and Related Fields
- Keywords
- research funding, genomics, genetic research, Africa, H3Africa, biomedical research funding, research funding allocation, research gaps, science policy, research funding agencies
- MeSH terms
- Africa, Capital Financing, Humans, Databases, Factual, Genomics, Biomedical Research
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