Effect of the BioEnterics intragastric balloon on weight, insulin resistance, and liver steatosis in obese patients
Abstract
Background In obese patients, positioning of the BioEnterics intragastric balloon (BIB) proved beneficial for weight loss, but the effect of the device on ameliorating some components of the metabolic syndrome associated with obesity remains uncertain. Objective To evaluate the effectiveness of BIB insertion on weight control and amelioration of components of the metabolic syndrome. Design A prospective intervention study performed at baseline, 6 months after BIB insertion, and after a mean (standard deviation [SD]) of 21 (3) months (range 14-26) of follow-up. Setting Division of Gastroenterology and Endoscopic Unit, "Casa Sollievo della Sofferenza" Hospital. Patients One hundred thirty obese patients with a mean (SD) weight of 118 (24) kg and mean (SD) body mass index (BMI) of 43 (8) kg/m(2). Interventions Positioning of BIB. Main outcome measurements Anthropometric and laboratory parameters. Results Overall, the mean (SD) weight and BMI decreased by 13.2 (8.2) kg and 5.1 (3.2) kg/m(2), respectively, compared with baseline. The mean glycemia, insulinemia, Homeostasis Model Assessment index, triglyceridemia, and alanine aminotransferase levels were significantly reduced. In the 91 responders (BMI decrease of > or = 3.5 kg/m(2)), the mean (SD) weight and BMI decreased by 16.4 (6.3) kg and 6.4 (2.3) kg/m(2), respectively, and severe liver steatosis decreased from 52% to 4% (P < .0001). On multivariate analysis, severe steatosis and the Homeostasis Model Assessment index were predictive of the response to BIB: odds ratios of 6.71 (95% CI, 2.23-20.19) and 3.18 (95% CI, 1.20-8.42). After a median follow-up of 22 months after BIB removal, 50% of responders maintained or continued to lose weight. Limitations No sham-treated patients were included as comparative controls. Conclusions Treatment was effective in inducing weight loss, improving liver steatosis, and restoring some components of the metabolic syndrome.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
IGB therapy reduces severe hepatic steatosis from 52% pre-treatment to 4% after six months.
“Prospective findings further corroborated these results, documenting severe hepatic steatosis decline from 52% pre-treatment to just 4% after six months (p < 0.0001) [74].”
From Impact of Bariatric Surgery and Endoscopic Therapies on Liver Health in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review (2025) · cites this paper as [74]
IGB therapy reduces abnormal ALT levels from 38% to 7% at six months.
“a prospective evaluation demonstrated abnormal ALT levels dropping from 38% to 7% at six months [74]”
From Impact of Bariatric Surgery and Endoscopic Therapies on Liver Health in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review (2025) · cites this paper as [74]
IGB reduces ALT by 20.3-38%.
“Other procedures showed variable ALT reductions: IGB (20.3–38%) [74,76], DMR (29.3%) [94], and ESG (16%) [83].”
From Impact of Bariatric Surgery and Endoscopic Therapies on Liver Health in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review (2025) · cites this paper as [74]
Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · see citing works
Effects of Bariatric Surgery on Mortality in Swedish Obese Subjects
Sjöström, L., Narbro, K., Sjöström, C. D., Karason, K., Larsson, B., Wedel, H., Lystig, T., Sullivan, M., Bouchard, C., Carlsson, B., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066254 · Cited by 4,668 · see citing works
Epidemiologic aspects of overweight and obesity in the United States☆
FLEGAL, K. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.050 · Cited by 284 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Kumar, N. (2015) · World Journal of Gastrointestinal Endoscopy · doi:10.4253/wjge.v7.i9.847 · Cited by 90 · see citing works
Risi, R., Rossini, G., Tozzi, R., Pieralice, S., Monte, L., Masi, D., Castagneto-Gissey, L., Gallo, I. F., Strigari, L., Casella, G., et al. (2022) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2022.03.022 · Cited by 68 · see citing works
Chandan, S., Mohan, B. P., Khan, S. R., Facciorusso, A., Ramai, D., Kassab, L. L., Bhogal, N., Asokkumar, R., Lopez-Nava, G., McDonough, S., et al. (2021) · Obesity Surgery · doi:10.1007/s11695-020-05084-0 · Cited by 46 · see citing works
Effect of intragastric balloons on liver enzymes: A systematic review and meta-analysis
Popov, V. B., Thompson, C. C., Kumar, N., Ciarleglio, M. M., Deng, Y., & Laine, L. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4178-2 · Cited by 43 · see citing works
Authors, & Collaborators: (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1880-2388 · Cited by 30 · see citing works
Tasabehji, D., Saleh, S., & Mokadem, M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14124012 · Cited by 14 · see citing works
- Authors
- Forlano, R., Ippolito, A. M., Iacobellis, A., Merla, A., Valvano, M. R., Niro, G., Annese, V., & Andriulli, A.
- Affiliations
- Casa Sollievo della Sofferenza (IT)
- Corresponding author
- Andriulli, Angelo
- ORCID
- Venue
- Gastrointestinal Endoscopy
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 71
- Issue
- 6
- Pages
- 927-933
- ISSN
- 0016-5107 (ISSN-L)
- OpenAlex
- W2057412428
- Cited by
- 104
- References
- 3
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 6 · 2022: 9 · 2021: 8 · 2020: 12 · 2019: 2 · 2018: 5 · 2017: 4 · 2016: 14 · 2015: 8 · 2014: 5 · 2013: 7 · 2012: 6
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastrointestinal Endoscopy (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Health Sciences › Medicine › Surgery › Minimally Invasive Surgical Techniques
- Keywords
- obesity, weight loss, insulin resistance, hepatic steatosis, metabolic syndrome, HOMA-IR, triglyceridemia, alanine aminotransferase, predictors of treatment response, long-term weight maintenance, non-surgical obesity treatment, body mass index reduction, glycemia, insulin levels
- MeSH terms
- Adult, Fatty Liver, Female, Humans, Insulin Resistance, Male, Middle Aged, Obesity, Prospective Studies, Gastroplasty, Weight Loss, Gastric Balloon, Metabolic Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
