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Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment
Open accessAbstract
Background and aims Pancreatic cancer organoids are tumor models of individualized human pancreatic ductal adenocarcinoma (PDA), created from surgical specimens and used for personalized treatment strategies. Unfortunately, most patients with PDA are not operative candidates. Creation of human PDA organoids at the time of initial tumor diagnosis is therefore critical. Our aim was to assess the feasibility of creating human PDA organoids by EUS fine-needle biopsy (EUS-FNB) sampling in patients with PDA.Methods In this prospective clinical trial in patients referred to evaluate a pancreatic mass, EUS-FNA was performed for initial onsite diagnosis. Two additional needle passes were performed with a 22-gauge FNB needle for organoid creation. Primary outcome was successful isolation of organoids within 2 weeks of EUS-FNB sampling (P0, no passages), confirmed by organoid morphology and positive genotyping.Results Thirty-seven patients with 38 PDA tumors were enrolled. Successful isolation of organoids (P0) was achieved in 33 of 38 tumors (87%). Establishment of PDA organoid lines for ≥5 passages of growth (P5, five passages) was reached in 25 of 38 tumors (66%). In the single patient with successful P5 FNB sampling-derived and P5 surgically derived organoids, there was identical matching of specimens. There were no serious adverse events. Two patients developed bleeding at the EUS-FNB puncture site requiring hemostasis clips.Conclusions Pancreatic cancer organoids can be successfully and rapidly created by means of EUS-FNB sampling using a 22-gauge needle at the time of initial diagnosis. Successful organoid generation is essential for precision medicine in patients with pancreatic cancer in whom most are not surgically resectable. (Clinical trial registration number: NCT03140592.).
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“Tumor tissue, derived from either biopsies or surgical resections, is also typically processed akin to normal tissue to isolate tumour cells to grow as organoids16,49–51.”
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“Tumor cells isolated from liquid samples such as peripheral blood52, ascites50,53, and pleural effusions54 can also be used as starting material to generate organoids.”
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Cites
Spencer, P. M., Cameron, J. L., & Lin, L. (2000) · Cited by 7,202
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Öhlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162024 · Cited by 2,590
Self-citationHidalgo, M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0901557 · Cited by 2,570
Organoid models of human and mouse ductal pancreatic cancer
Boj, S. F., Hwang, C.-I., Baker, L. A., Chio, I. I. C., Engle, D. D., Corbo, V., Jager, M., Ponz-Sarvise, M., Tiriac, H., Spector, M. S., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.021 · Cited by 2,150
Self-citationAdvanced pancreatic carcinoma: current treatment and future challenges
Stathis, A., & Moore, M. J. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2009.236 · Cited by 791
EUS-guided FNA for diagnosis of solid pancreatic neoplasms: a meta-analysis
Hewitt, M. J., McPhail, M. J. W., Possamai, L. A., Dhar, A., Vlavianos, P., & Monahan, K. J. (2012) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2011.08.049 · Cited by 694
Organoids: A historical perspective of thinking in three dimensions
Simian, M., & Bissell, M. J. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201610056 · Cited by 620
An In vivo Platform for Translational Drug Development in Pancreatic Cancer
Rubio‐Viqueira, B., Jimeno, A., Cusatis, G., Zhang, X., Iacobuzio–Donahue, C. A., Karikari, C. A., Shi, C., Danenberg, K. D., Danenberg, P. V., Kuramochi, H., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0113 · Cited by 422
Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient mice
Kim, M. P., Evans, D. B., Wang, H., Abbruzzese, J. L., Fleming, J. B., & Gallick, G. E. (2009) · Nature Protocols · doi:10.1038/nprot.2009.171 · Cited by 383
Bang, J. Y., Hébert‐Magee, S., Trevino, J., Ramesh, J., & Varadarajulu, S. (2012) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2012.03.1392 · Cited by 269
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- Nagula, 2017, Comparing EUS-fine needle aspiration and EUS-fine needle biopsy for solid lesions: a multicenter, randomized trial, Clin Gastroenterol Hepatol. Epub
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Sorted by citations
Items 101–164 of 164
Søreide, K., Primavesi, F., Labori, K. J., Watson, M. M., & Stättner, S. (2019) · European surgery. Supplement/European surgery · doi:10.1007/s10353-019-0575-z · Cited by 10
Archibugi, L., Testoni, S. G. G., Redegalli, M., Petrone, M. C., Reni, M., Falconi, M., Doglioni, C., Capurso, G., & Arcidiacono, P. G. (2019) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v11.i11.933 · Cited by 10
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Welm, B. E., Vaklavas, C., & Welm, A. L. (2021) · APL Bioengineering · doi:10.1063/5.0030534 · Cited by 10
Pancreatic Cancer Organoids: Modeling Disease and Guiding Therapy
Morceau, F., El‐Khoury, V., Lee, K., Berna, M. J., & Kwon, Y. (2025) · Cancers · doi:10.3390/cancers17233850 · Cited by 10
Xing, F., Ai, N., Huang, S., Jiang, C., Jameel, M., Ge, W., Wang, G., & Deng, C. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.839078 · Cited by 9
Endoscopic Ultrasound-Guided Sampling for Personalized Pancreatic Cancer Treatment
Iwasaki, E., Fukuhara, S., Horibe, M., Kawasaki, S., Seino, T., Takimoto, Y., Tamagawa, H., Machida, Y., Kayashima, A., Noda, M., et al. (2021) · Diagnostics · doi:10.3390/diagnostics11030469 · Cited by 9
ISHIDA, Y., Tsunoda, T., HAMADA, Y., Tsuchiya, N., Koga, T., KITAGUCHI, T., MATSUMOTO, K., MATSUMOTO, S., Sasaki, T., Nakashima, R., et al. (2022) · Anticancer Research · doi:10.21873/anticanres.15908 · Cited by 9
Kim, S., Woo, K. J., Yang, C.-M., Park, S. H., Hwang, J. C., Yoo, B. M., Kim, J. H., Lee, D., & Yang, M. J. (2023) · Digestive Endoscopy · doi:10.1111/den.14648 · Cited by 9
Self-citationWiessner, J. R., Orben, F., Schäfer, A., Fricke, L., Schneider, G., Reichert, M., Herner, A., Mayr, U., Phillip, V., Treiber, M., et al. (2024) · Endoscopy International Open · doi:10.1055/a-2257-3171 · Cited by 8
Lee, H. S., Kim, E., Lee, J., Park, S. J., Hwang, H. K., Park, C. H., Jo, S.-Y., Kang, C. M., Hong, S., Kang, H., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103218 · Cited by 8
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Zerdan, M. B., Shatila, M., Sarwal, D., Bouferraa, Y., Zerdan, M. B., Allam, S., Ramovic-Zobic, M., & Graziano, S. L. (2022) · Cancers · doi:10.3390/cancers14194589 · Cited by 7
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Nelson, S. R., & Walsh, N. (2020) · Cancers · doi:10.3390/cancers12051233 · Cited by 8
Vasiliadou, I., Cattaneo, C., Chan, P. Y. K., Henley‐Smith, R., Gregson-Williams, H., Collins, L., Wojewodka, G., Urbano, T. G., Jeannon, J., Connor, S. E. J., et al. (2024) · BMJ Open · doi:10.1136/bmjopen-2024-084176 · Cited by 9
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Jiao, C., Karakaya, O. F., Dadgar, N., Wehrle, C. J., Massoud, Z., Hong, H., Fairchild, R. L., Leipzig, N. D., Aucejo, F., Ma, W. W., et al. (2026) · MedComm · doi:10.1002/mco2.70571 · Cited by 9
Isolation and Characterization of Patient-derived Pancreatic Ductal Adenocarcinoma Organoid Models
Tiriac, H., French, R. P., & Lowy, A. M. (2020) · Journal of Visualized Experiments · doi:10.3791/60364 · Cited by 6
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Amada, K., Hijiya, N., Ikarimoto, S., Yanagihara, K., Hanada, T., Hidano, S., Kurogi, S., Tsukamoto, Y., Nakada, C., Kinoshita, K., et al. (2023) · Cancer Science · doi:10.1111/cas.15735 · Cited by 5
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Hedayat, S., & Valeri, N. (2020) · Clinical Oncology · doi:10.1016/j.clon.2019.12.009 · Cited by 5
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Upreti, K., Mittal, S., Vats, P., Haque, M., Pawar, V. V., & Haque, M. (2023) · Communications in computer and information science · doi:10.1007/978-3-031-45121-8_3 · Cited by 3
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Caruso, A., Delvecchio, A., Memeo, R., Lanzino, M., & Martinotti, S. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1872361 · Cited by 3
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Chudakova, D. A., Skorova, E., & Reshetov, I. V. (2020) · Biotekhnologiya · doi:10.21519/0234-2758-2020-36-3-3-15 · Cited by 1
de Moraes, L. B. D. C. E. A. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.46.2019.tde-07052019-110949 · Cited by 1
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He, B. J. (2021) · Georgetown Scientific Research Journal · doi:10.48091/gsr.v1i2.21
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Maeng, J. E., Kim, S., Song, M.-H., Jeong, N., & Ku, J. (2022) · Journal of Digestive Cancer Research · doi:10.52927/jdcr.2022.10.2.82
Weston, B. R., & Coronel, E. S. (2022) · Springer eBooks · doi:10.1007/978-3-031-05724-3_7
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Osorio-Vasquez, V., Zhu, J., Lumibao, J. C., Lande, K., Peck, K. L., Stamp, M. K., Okhovat, S. R., Song, H., Ogawa, S., Kubota, C. S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.30.620903
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Than, X. Y., Ong, T. T., & Chow, E. K. (2024) · World Scientific Annual Review of Cancer Immunology · doi:10.1142/s2972389224300019
Schuth, S., Blanc, S. L., Krieger, T. G., Jabs, J., Schenk, M., Giese, N. A., Büchler, M. W., Eils, R., Conrad, C., & Strobel, O. (2022) · Figshare · doi:10.6084/m9.figshare.21384592
Schuth, S., Blanc, S. L., Krieger, T. G., Jabs, J., Schenk, M., Giese, N. A., Büchler, M. W., Eils, R., Conrad, C., & Strobel, O. (2022) · Figshare · doi:10.6084/m9.figshare.21384589
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Li, T., Wang, X., Zhu, M., Han, S., Zhao, D., Wong, V. H. H., Huang, W., Li, Z., Zhao, H., & Qian, X. (2025) · Discover Oncology · doi:10.1007/s12672-025-03963-5
Gouirand, V. (2018) · theses.fr (ABES) · doi:10.70675/fff49f3ezaf3bz4eaaz80f7z7dd647ad95a1
Patient-derived organoids in pancreatic cancer: Advances and applications in precision oncology
Lee, H. S., & Koo, B. (2026) · Cancer Biome and Targeted Therapy · doi:10.66505/cbtt.v1i3.46
Cappello, P., Gentiluomo, M., Giovannetti, E., Lonardo, E., Luchini, C., Marchesi, F., Carnaghi, C., Paiella, S., & Carrara, S. (2026) · Digestive and Liver Disease · doi:10.1016/j.dld.2026.08.021
Autorinnen/Autoren, & Coautoren (2026) · Zeitschrift für Gastroenterologie · doi:10.1055/a-2822-0395
Metadata
- Authors
- Tiriac, H., Bucobo, J. C., Tzimas, D., Grewel, S., Lacomb, J. F., Rowehl, L. M., Nagula, S., Wu, M., Kim, J., Sasson, A., Vignesh, S., Martello, L., Munoz-Sagastibelza, M., Somma, J., Tuveson, D. A., Li, E., & Buscaglia, J. M.
- Affiliations
- Stony Brook School (US)
- SUNY Downstate Health Sciences University (US)
- Cold Spring Harbor Laboratory (US)
- Corresponding author
- Buscaglia, Jonathan M.
- ORCID
- Venue
- Gastrointestinal Endoscopy
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 87
- Issue
- 6
- Pages
- 1474-1480
- ISSN
- 0016-5107 (ISSN-L)
- PMC
- PMC6143289
- OpenAlex
- W2608725539
- Cited by
- 164
- References
- 30
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 20 · 2023: 12 · 2022: 31 · 2021: 26 · 2020: 30 · 2019: 17 · 2018: 9
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gastrointestinal Endoscopy (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (submittedVersion)
- Funders
- Boston Scientific Corporation
- Stony Brook University
- National Institutes of Health (5p30ca045508-35)
- National Cancer Institute (P20CA192996, P50CA101955, R01CA188134, U10CA180944, P20CA192994, U01CA168409, P30-CA045508, R01CA190092)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- pancreatic ductal adenocarcinoma, pancreatic cancer organoids, EUS-guided fine-needle biopsy, precision oncology, precision medicine, unresectable pancreatic cancer, endoscopic ultrasound-guided fine-needle aspiration
- MeSH terms
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Organoids, Pancreatic Neoplasms, Tumor Cells, Cultured, Carcinoma, Pancreatic Ductal, Tissue Culture Techniques, Precision Medicine, Endoscopic Ultrasound-Guided Fine Needle Aspiration
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