Propofol sedation with a target-controlled infusion pump in elderly patients undergoing ERCP
Abstract
Background and aims Advanced age is an important risk factor for adverse events (AEs) during propofol sedation for endoscopic procedures. This study aimed to evaluate the safety and efficacy of nonanesthesiologist-administered propofol (NAAP) sedation with a target-controlled infusion (TCI) system in elderly patients during ERCP. Methods This study retrospectively analyzed 482 patients who underwent ERCP under propofol sedation with a TCI system at Iwakuni Medical Center between January 2014 and October 2016. Patients were divided into 3 groups according to their age: group A, Results The median total infusion dose and minimum and maximum target blood concentrations of propofol were 336 mg, 2.2 μg/mL, and 2.2 μg/mL in group A; 184 mg, 1.0 μg/mL, and 1.4 μg/mL in group B; and 99 mg, .6 μg/mL, and 1.0 μg/mL in group C, respectively, with older groups requiring a lower dose (P Conclusions NAAP sedation with a TCI system during ERCP may be acceptable in elderly patients with a lower dose of propofol than that used in younger patients.
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Propofol-based general anesthesia has cardiopulmonary side effects, including hypoxia, hypotension, arrhythmia, respiratory depression, injection pain, and fatal metabolic derangement.
“However, propofol-based general anesthesia has certain cardiopulmonary side effects, including hypoxia, hypotension, arrhythmia, respiratory depression, and other adverse reactions, such as injection pain and fatal metabolic derangement (5).”
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References 24 · Cited by 50
- Authors
- Ogawa, T., Tomoda, T., Kato, H., Akimoto, Y., Tanaka, S., & Okada, H.
- Affiliations
- Okayama University (JP)
- Iwakuni Medical Center (JP)
- Corresponding author
- Ogawa, Taiji
- Venue
- Gastrointestinal Endoscopy
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 92
- Issue
- 2
- Pages
- 301-307
- ISSN
- 0016-5107 (ISSN-L)
- OpenAlex
- W3010368269
- Cited by
- 50
- References
- 24
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 11 · 2023: 14 · 2022: 5 · 2021: 5 · 2020: 4
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastrointestinal Endoscopy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Health Sciences › Veterinary › Small Animals › Veterinary Pharmacology and Anesthesia
- Physical Sciences › Engineering › Biomedical Engineering › Intravenous Infusion Technology and Safety
- Keywords
- propofol sedation, target-controlled infusion, elderly patients, endoscopic retrograde cholangiopancreatography, propofol dose, adverse events, hypotension, hypoxemia, old age
- MeSH terms
- Aged, Cholangiopancreatography, Endoscopic Retrograde, Humans, Hypnotics and Sedatives, Hypotension, Infusion Pumps, Retrospective Studies, Propofol, Procedural Sedation
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