Irreversible electroporation (NanoKnife) in cancer treatment
Open accessAbstract
Irreversible electroporation (IRE) is a promising new minimally invasive modality for the ablation of solid tumors. Unlike the current leading thermal ablation modalities, such as radiofrequency ablation (RFA) and cryoablation, IRE uses nonthermal electric energy to irreversibly destabilize cell membranes, resulting in focused cell death. Over the past 7 years, IRE has been emerging as a novel ablation tool by using the effect of an applied electric field to kill cancer cells, without damaging the surrounding extracellular matrix, vessels, nerves, and neighboring normal tissue. Although IRE has been investigated for a short period of time, its potential use for cancer and tissue ablation has been receiving growing attention leading to a considerable number of studies on its validity and safety, including recent in vivo animal and human studies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Various studies have shown the effectiveness of using irreversible electroporation to induce tumor ablation and suggest that its ability to target malignant cells is due to plasma membrane differences between cancer and non-cancer cells.
“Various studies have shown the effectiveness of using irreversible electroporation to induce tumor ablation and suggest that its ability to target malignant cells is due to plasma membrane differences between cancer and non-cancer cells [67,68].”
From Permeabilizing Cell Membranes with Electric Fields (2021) · cites this paper as [67]
The relatively depolarized resting Vm in cancer cells could explain why, compared to non-cancer cells, cancer cells are more vulnerable to both electroporation and TTFields.
“The relatively depolarized resting Vm in cancer cells [28,29,30,31,73,74,75] could explain why, compared to non-cancer cells, cancer cells are more vulnerable to both electroporation and TTFields [67,69] (see Table S4).”
From Permeabilizing Cell Membranes with Electric Fields (2021) · cites this paper as [67]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 106 · Cited by 99
Research works printed but not linked: 5
- Davalos RV, Mir IL, Rubinsky B. Tissue ablation with irreversible electropo- ration. Ann Biomed Eng. 2005;33:223-31.
- Rubinsky B, Onik G, Mikus P. Irreversible electroporation: a new ablation modalitydclinical implications. Technol Cancer Res Treat. 2007;6:37-48.
- Heller R, Gilbert R, Jaroszeski MJ. Clinical applications of electro- chemotherapy. Adv DrugDdelivery Rev. 1994;35:119-29.
- Mali B, Jarm T, Jager F, Miklavcic D. An algorithm for synchronization of in vivo electroporation with ECG. J Med Eng Technol. 2005;29:288-96.
- Garcia PA, Neal RE, Rossmeisl JH, Davalos RV. Nonthermal irreversible elec- troporation for deep intracranial disorders. Conf Proc IEEE Eng Med Biol Soc. 2010;2010:2743-6.
- Authors
- Jourabchi, N., Beroukhim, K., Tafti, B. A., Kee, S. T., & Lee, E. W.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Lee, Edward W.
- ORCID
- Lee, Edward W.
- Venue
- Gastrointestinal Intervention
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 3
- Issue
- 1
- Pages
- 8-18
- ISSN
- 2213-1795 (ISSN-L)
- OpenAlex
- W2091246492
- Cited by
- 99
- References
- 106
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 5 · 2023: 14 · 2022: 7 · 2021: 15 · 2020: 4 · 2019: 8 · 2018: 8 · 2017: 11 · 2016: 8 · 2015: 2 · 2014: 4
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Gastrointestinal Intervention (publishedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Inactivation Methods
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Plasma Applications and Diagnostics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Keywords
- irreversible electroporation, NanoKnife, solid tumor ablation, non-thermal ablation, cancer cell death, minimally invasive cancer treatment, radiofrequency ablation comparison
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
