The DOI matches its Crossref record; 161 of the 161 references it cites were found in a registry or an index.
Pharmacogenomics of Drug Metabolizing Enzymes and Transporters: Relevance to Precision Medicine
Open accessAbstract
The interindividual genetic variations in drug metabolizing enzymes and transporters influence the efficacy and toxicity of numerous drugs. As a fundamental element in precision medicine, pharmacogenomics, the study of responses of individuals to medication based on their genomic information, enables the evaluation of some specific genetic variants responsible for an individual’s particular drug response. In this article, we review the contributions of genetic polymorphisms to major individual variations in drug pharmacotherapy, focusing specifically on the pharmacogenomics of phase-I drug metabolizing enzymes and transporters. Substantial frequency differences in key variants of drug metabolizing enzymes and transporters, as well as their possible functional consequences, have also been discussed across geographic regions. The current effort illustrates the common presence of variability in drug responses among individuals and across all geographic regions. This information will aid health-care professionals in prescribing the most appropriate treatment aimed at achieving the best possible beneficial outcomes while avoiding unwanted effects for a particular patient.
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Cited by
Vinarov, Z., Abdallah, M., Agundez, J. A. G., Allegaert, K., Basit, A. W., Braeckmans, M., Ceulemans, J., Corsetti, M., Griffin, B. T., Grimm, M., et al. (2021) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2021.105812 · Cited by 359
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Mitophagy and cGAS–STING crosstalk in neuroinflammation
Zhou, X., Wang, J., Yu, L., Qiao, G., Qin, D., Yuen-Kwan Law, B., Ren, F., Wu, J., & Wu, A. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.05.012 · Cited by 131
Tomlinson, L., Ramsden, D., Leite, S. B., Beken, S., Bonzo, J. A., Brown, P., Candarlioglu, P. L., Chan, T. S., Chen, E., Choi, C. K., et al. (2024) · Advanced Biology · doi:10.1002/adbi.202300131 · Cited by 33
Drug-Metabolizing Gene Expression Identity: Comparison Across Liver Tissues and Model Cell Lines
Arzumanian, V. A., Timofeeva, E. V., Kiseleva, O. I., & Poverennaya, E. V. (2025) · Biomedicines · doi:10.3390/biomedicines13112722 · Cited by 11
Metadata
- Authors
- Ahmed, S., Zhou, Z., Zhou, J., & Chen, S.-Q.
- Venue
- Genomics, Proteomics & Bioinformatics
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-10-01
- Volume
- 14
- Issue
- 5
- Pages
- 298-313
- ISSN
- 1672-0229 (ISSN-L)
- 2210-3244
- OpenAlex
- W2528806650
- Cited by
- 371
- References
- 161
- FWCI
- 21.84
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ahmed, S., Zhou, Z., Zhou, J., & Chen, S.-Q. (2016). Pharmacogenomics of Drug Metabolizing Enzymes and Transporters: Relevance to Precision Medicine. Genomics, Proteomics & Bioinformatics. https://doi.org/10.1016/j.gpb.2016.03.008
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