The Role of Diet in the Treatment of Irritable Bowel Syndrome
Abstract
Irritable bowel syndrome (IBS) is a multifaceted illness involving maladaptive shifts in the gut microbiota that affect the enteric nervous and immune systems, mucosal barrier function, the balance of neurotransmitters and hormones, and emotional well-being. There is abundant evidence indicating that certain foods elicit symptoms in IBS. Numerous elimination-type diets have been shown to alleviate symptoms. However, among these, the most controversial is a group of foods called fructo, oligo-, di-, and monosaccharides and polyols (FODMAPs). This paper reviews the role of diet and systematically analyze the literature for the role of FODMAPs in IBS.
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The gut microbiome influences serotonin production and secretion as a direct result of the food we eat (in particular the amount of Trp), as diet modulates microbial composition.
“The gut microbiome influences serotonin production and secretion as a direct result of the food we eat (in particular the amount of Trp), as diet modulates microbial composition [46].”
From Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders (2022) · cites this paper as [46]
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References 122 · Cited by 42
- Authors
- Singh, R., Salem, A., Nanavati, J., & Mullin, G. E.
- Affiliations
- Sinai Hospital (US)
- University of Rochester Medicine (US)
- Johns Hopkins University (US)
- Corresponding author
- Mullin, Gerard E.
- Venue
- Gastroenterology Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 47
- Issue
- 1
- Pages
- 107-137
- ISSN
- 0889-8553 (ISSN-L)
- OpenAlex
- W2784490881
- Cited by
- 42
- References
- 122
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 3 · 2019: 7 · 2018: 4
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Keywords
- irritable bowel syndrome, diet, FODMAPs, elimination diet, gut microbiota, gut-brain-immune axis, mucosal barrier function, food intolerance, symptom management
- MeSH terms
- Dietary Sugars, Alcoholic Beverages, Caffeine, Capsaicin, Dairy Products, Diet, Dietary Fats, Dietary Fiber, Food, Food Hypersensitivity, Humans, Irritable Bowel Syndrome, Diet, Gluten-Free
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