Mood and Microbes
Abstract
The gut microbiota, acting via the gut-brain axis, modulates key neurobiological systems that are dysregulated in stress-related disorders. Preclinical studies show that the gut microbiota exerts an influence over neuroimmune and neuroendocrine signaling pathways, in addition to epigenetic modification, neurogenesis, and neurotransmission. In humans, preliminary evidence suggests that the gut microbiota profile is altered in depression. The full impact of microbiota-based treatments, at different neurodevelopmental time points, has yet to be fully explored. The integration of the gut microbiota, as a mediator, in the complex trajectory of depression, may enhance the possibility of personalized precision psychiatry.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Transfer of faecal gut microbiota from humans with depression into rodents appears to induce animal behaviours that are hypothesised to indicate depression-like states.
“and transfer of faecal gut microbiota from humans with depression into rodents appears to induce animal behaviours that are hypothesised to indicate depression-like states.25 26”
From Food and mood: How do diet and nutrition affect mental wellbeing? (2020) · cites this paper as [26]
The citation lists haven’t been fetched yet
References 79 · Cited by 65
- Authors
- Kelly, J. R., Keane, V. O., Cryan, J. F., Clarke, G., & Dinan, T. G.
- Affiliations
- Trinity College Dublin (IE)
- University College Cork (IE)
- Corresponding author
- Dinan, Timothy G.
- Venue
- Gastroenterology Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2019-09
- Volume
- 48
- Issue
- 3
- Pages
- 389-405
- ISSN
- 0889-8553 (ISSN-L)
- OpenAlex
- W2953257138
- Cited by
- 65
- References
- 79
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 5 · 2023: 8 · 2022: 11 · 2021: 12 · 2020: 14 · 2019: 3
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Brain and Behavior Research Foundation (20771)
- National Alliance for Research on Schizophrenia and Depression
- Health Research Board (EUGRANT613979, HRA-POR-2-14-647, HRA_POR/2011/23, HRA_POR/2012/32, MYNEWGUTFP7-KBBE-2013-7)
- Science Foundation Ireland (SFI/12/RC/2273)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, gut-brain axis, depression, stress-related disorders, neuroimmune signaling, neuroendocrine signaling, epigenetic modifications, neurogenesis, neurotransmission, precision psychiatry
- MeSH terms
- Gastrointestinal Microbiome, Affect, Brain, Depression, Humans
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
