Indications of pro-inflammatory cytokines in laparoscopic and open liver resection for early-stage hepatocellular carcinoma
Open accessAbstract
Background Our clinical practice of laparoscopic liver resection (LLR) had achieved better short-term and long-term benefits for patients with hepatocellular carcinoma (HCC) over open liver resection (OLR), but the underlying mechanisms are not clear. This study was to find out whether systemic inflammation plays an important role. Methods A total of 103 patients with early-stage HCC under liver resection were enrolled (LLR group, n = 53; OLR group, n = 50). The expression of 9 inflammatory cytokines in patients at preoperation, postoperative day 1 (POD1) and POD7 was quantified by Luminex Multiplex assay. The relationships of the cytokines and the postoperative outcomes were compared between LLR and OLR. Results Seven of the circulating cytokines were found to be significantly upregulated on POD1 after LLR or OLR compared to their preoperative levels. Compared to OLR, the POD1 levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-6 (IL-6), IL-8, and monocyte chemoattractant protein-1 (MCP-1) in the LLR group were significantly lower. Higher POD1 levels of these cytokines were significantly correlated with longer operative time and higher volume of blood loss during operation. The levels of these cytokines were positively associated with postoperative liver injury, and the length of hospital stay. Importantly, a high level of IL-6 at POD1 was a risk factor for HCC recurrence and poor disease-free survival after liver resection. Conclusions Significa…
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Comparable patterns of IL-6 dynamics beside further cytokines have recently been reported in other contexts.
“Comparable patterns of IL-6 dynamics beside further cytokines have recently been reported in other contexts [45,46,47].”
From The Role of Perioperative Interleukin-6 Serum Levels on Liver Dysfunction and Infectious Complications After Hepatectomy—A Systematic Review (2025) · cites this paper as [45]
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Kofler, A., Trattner, M., Mairinger, V., Urban, I., Søreide, K., Stättner, S., & Primavesi, F. (2025) · Cancers · doi:10.3390/cancers17193120 · Cited by 4 · see citing works
“Comparable patterns of IL-6 dynamics beside further cytokines have recently been reported in other contexts [45–47].”
- Authors
- Ng, K. T.-P., Pang, L., Wang, J.-Q., She, W. H., Tsang, S. H.-Y., Lo, C. M., Man, K., & Cheung, T. T.
- Affiliations
- University of Hong Kong (HK)
- Corresponding author
- Cheung, Tan To
- Venue
- Hepatobiliary & Pancreatic Diseases International
- Publisher
- Elsevier BV
- Published
- 2024-06
- Volume
- 23
- Issue
- 3
- Pages
- 257-264
- ISSN
- 2352-9377 (ISSN-L)
- 1499-3872
- OpenAlex
- W4387827216
- Cited by
- 5
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- green
- hub.hku.hk
- Licence
- Locations
- Hepatobiliary & pancreatic diseases international (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion, cc-by-nc-nd)
- Funders
- Shenzhen Fundamental Research Program (JCYJ20210324114403010)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- laparoscopic liver resection, open liver resection, early hepatocellular carcinoma, inflammatory cytokines, systemic inflammation, interleukin-6, GM-CSF, interleukin-8, MCP-1, postoperative liver injury, HCC recurrence, disease-free survival, operative time, blood loss
- MeSH terms
- Hepatectomy, Carcinoma, Hepatocellular, Humans, Inflammation, Length of Stay, Liver Neoplasms, Laparoscopy, Postoperative Complications, Retrospective Studies, Interleukin-6, Granulocyte-Macrophage Colony-Stimulating Factor, Cytokines, Interleukin-8
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