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Factors indicative of long-term survival after lung transplantation: A review of 836 10-year survivors
Abstract
Introduction Despite 20 years of lung transplantation (LTx), factors influencing long-term survival remain largely unknown. The United Network for Organ Sharing (UNOS) data set provides an opportunity to examine long-term LTx survivors. Methods We conducted a case-control study embedded within the prospectively collected UNOS LTx cohort to identify 836 adults from 1987 to 1997 who survived >or=10 years after first LTx. LTx patients within the same era and surviving 1 to 5 years served as controls. Multivariable logistic regression with incorporation of spline terms evaluated the odds of being a 10-year survivor. Two separate models were constructed. Model A incorporated pre-operative, operative, and donor-specific factors. Model B incorporated the factors used in Model A with post-operative covariates. Additional outcomes evaluated included hospitalizations for infection, rejection, and bronchiolitis obliterans. Results Of 4,818 LTx patients from 1987 to 1997, 836 (17.3%) survived >or=10 years with a mean follow-up of 148.8 +/- 21.6 months. Mean follow-up for 1,657 controls was 34.0 +/- 13.9 months. The distribution of 10-year survivors by disease was cystic fibrosis, 170 (20%); chronic obstructive pulmonary disease, 254 (30%); and idiopathic pulmonary fibrosis, 92 (11%). On multivariable logistic regression, significant factors influencing 10-year survival included age <or=35 years (odds ratio [OR] 1.07, 95% confidence interval [CI], 1.03-1.11; p = 0.01), bilateral LTx (OR. 1.71; 95% CI, 1.25-2.34; p = 0.001), and hospitalizations for infections (OR, 1.40; 95% CI, 1.27-1.54; p < 0.001) and for rejection (OR, 0.55; 95% CI, 0.48-0.65; p < 0.001). Conclusions Examination of a cohort of long-term LTx survivors in the UNOS data set indicates that bilateral LTx and fewer hospitalizations for rejection may portend improved long-term survival after LTx.
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In an OPTN analysis of 92 adults with IPF transplanted from 1987 to 1997 who survived at least 10 years and 205 adults with IPF who died 1 to 5 years after transplantation, longer post-transplant survival was associated with BLT (29.4% of 10-year survivors underwent BLT vs. 14.6% of 1-5-year survivors, P = 0.003).
“An analysis of the OPTN data that included 92 (27 BLT) adults with IPF transplanted from 1987 to 1997 who survived ≥10 years after their first lung transplant and 205 (30 BLT) adults with IPF who received an allograft within the same era (1987–1997) and died between 1 and 5 years after lung transplantation, found that longer post-transplant survival among IPF patients was associated with BLT – 29.”
From Lung transplantation in idiopathic pulmonary fibrosis: a systematic review of the literature (2014) · cites this paper as [54]
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Research works printed but not linked: 19
- Christie, 2008, Registry of the International Society for Heart and Lung Transplantation: twenty-fifth official adult lung and heart/lung transplantation report—2008, J Heart Lung Transplant, 27, 957, 10.1016/j.healun.2008.07.018 · DOI
- Sharples, 2002, Risk factors for bronchiolitis obliterans: a systematic review of recent publications, J Heart Lung Transplant, 21, 271, 10.1016/S1053-2498(01)00360-6 · DOI
- Smits, 2003, Predictors of lung transplant survival in Eurotransplant, Am J Transplant, 3, 1400, 10.1046/j.1600-6143.2003.00231.X · DOI
- Thabut, 2008, Survival after bilateral versus single lung transplantation for patients with chronic obstructive pulmonary disease: a retrospective analysis of registry data, Lancet, 371, 744, 10.1016/S0140-6736(08)60344-X · DOI
- Trulock, 2006, Registry of the International Society for Heart and Lung Transplantation: twenty-third official adult lung and heart-lung transplantation report—2006, J Heart Lung Transplant, 25, 880, 10.1016/j.healun.2006.06.001 · DOI
- Weiss, 2009, Impact of advanced age in lung transplantation: an analysis of United Network for Organ Sharing data, J Am Coll Surg, 208, 400, 10.1016/j.jamcollsurg.2008.12.010 · DOI
- Weiss, 2008, Outcomes in bicaval versus biatrial techniques in heart transplantation: an analysis of the UNOS database, J Heart Lung Transplant, 27, 178, 10.1016/j.healun.2007.11.003 · DOI
- de Perrot, 2004, Twenty-year experience of lung transplantation at a single center: influence of recipient diagnosis on long-term survival, J Thorac Cardiovasc Surg, 127, 1493, 10.1016/j.jtcvs.2003.11.047 · DOI
- Hosenpud, 1994, The effect of transplant center volume on cardiac transplant outcome, JAMA, 271, 1844, 10.1001/jama.1994.03510470048033 · DOI
- Weiss, 2008, Increased mortality at low-volume orthotopic heart transplantation centers: should current standards change?, Ann Thorac Surg, 86, 1250, 10.1016/j.athoracsur.2008.06.071 · DOI
- Hadjiliadis, 2006, Controversies in lung transplantation: are two lungs better than one?, Semin Respir Crit Care Med, 27, 561, 10.1055/s-2006-954613 · DOI
- Nwakanma, 2007, Impact of bilateral versus single lung transplantation on survival in recipients 60 years of age and older: analysis of United Network for Organ Sharing database, J Thorac Cardiovasc Surg, 133, 541, 10.1016/j.jtcvs.2006.09.062 · DOI
- Rinaldi, 2008, Single versus double lung transplantation in pulmonary fibrosis: a debated topic, Transplant Proc, 40, 2010, 10.1016/j.transproceed.2008.05.052 · DOI
- Mason, 2007, Lung transplantation for idiopathic pulmonary fibrosis, Ann Thorac Surg, 84, 1121, 10.1016/j.athoracsur.2007.04.096 · DOI
- Kroshus, 1997, Risk factors for the development of bronchiolitis obliterans syndrome after lung transplantation, J Thorac Cardiovasc Surg, 114, 195, 10.1016/S0022-5223(97)70144-2 · DOI
- Bando, 1995, Obliterative bronchiolitis after lung and heart-lung transplantation, J Thorac Cardiovasc Surg, 110, 4, 10.1016/S0022-5223(05)80003-0 · DOI
- Heng, 1998, Bronchiolitis obliterans syndrome: incidence, natural history, prognosis, and risk factors, J Heart Lung Transplant, 17, 1255
- El-Gamel, 1999, Transforming growth factor beta (TGF-beta) and obliterative bronchiolitis following pulmonary transplantation, J Heart Lung Transplant, 18, 828, 10.1016/S1053-2498(99)00047-9 · DOI
- Norgaard, 1998, Does bronchial artery revascularization influence results concerning bronchiolitis obliterans syndrome and/or obliterative bronchiolitis after lung transplantation?, Eur J Cardiothorac Surg, 14, 311, 10.1016/S1010-7940(98)00182-1 · DOI
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Lung transplantation in idiopathic pulmonary fibrosis: a systematic review of the literature
Kistler, K. D., Nalysnyk, L., Rotella, P., & Esser, D. (2014) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-14-139 · Cited by 151
Twenty-year survival following lung transplantation
Miggins, J. J., Reul Jr, R. M., Barrett, S., Rana, A., Alnajar, A., Dunson, J., Shafii, A., Garcha, P., Goss, J., & Loor, G. (2023) · Journal of Thoracic Disease · doi:10.21037/jtd-22-1414 · Cited by 8
“For instance, Weiss et al. demonstrated a doubled 10-year survival rate among younger patients receiving bilateral LTx compared to unilateral (16).”
Metadata
- Authors
- Weiss, E. S., Allen, J. G., Merlo, C. A., Conte, J. V., & Shah, A. S.
- Affiliations
- Johns Hopkins University (US)
- Johns Hopkins Hospital (US)
- Venue
- The Journal of Heart and Lung Transplantation
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 29
- Issue
- 3
- Pages
- 240-246
- ISSN
- 1053-2498 (ISSN-L)
- OpenAlex
- W2026813658
- Cited by
- 46
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 7 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 1 · 2016: 7 · 2014: 4 · 2013: 1 · 2012: 2
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Heart and Lung Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (234-2005-370011 C)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007713)
- Topics
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Organ Donation and Transplantation
- Keywords
- lung transplantation, long-term survival, bilateral lung transplantation, age at transplantation, infection hospitalization, graft rejection, bronchiolitis obliterans, cystic fibrosis, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, preoperative risk factors, postoperative risk factors, United Network for Organ Sharing registry, risk stratification
- MeSH terms
- Adult, Bronchiolitis Obliterans, Cystic Fibrosis, Female, Follow-Up Studies, Graft Rejection, Humans, Male, Middle Aged, Prospective Studies, Registries, Respiratory Tract Infections, Retrospective Studies, Incidence, Logistic Models, Case-Control Studies, Lung Transplantation, Survivors, Pulmonary Disease, Chronic Obstructive, Idiopathic Pulmonary Fibrosis
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