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Cited by 50Transplantation: Methods and OutcomesCardiovascular and exercise physiologyMedical Practices and Rehabilitation

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Effect of inpatient rehabilitation on quality of life and exercise capacity in long-term lung transplant survivors: A prospective, randomized study

Ihle, Franziska, Neurohr, Claus, Huppmann, Patrick, Zimmermann, Gregor, Leuchte, Hanno, Baumgartner, Rainier, Kenn, Klaus, Sczepanski, Bernd, Hatz, Rudolf, Czerner, Stephan, Frey, Lorenz, Ueberfuhr, Peter, Bittmann, Iris, Behr, Jürgen·2011·The Journal of Heart and Lung Transplantation
DOI 10.1016/j.healun.2011.02.006
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Abstract

Background The purpose of this study was to examine the effect of an inpatient rehabilitation program on health-related quality of life (HRQOL) and exercise capacity (EC) in long-term (>1 year after lung transplantation) survivors (LTSs) in comparison to a control group (CG). Methods Sixty LTSs, 4.5 ± 3.2 years after lung transplantation (LTx), were randomly assigned to two equally sized groups that were stratified for gender and underlying disease. Thirty LTSs (age 49 ± 13 years, 13 male and 17 females, 19 double LTxs, 7 BOS Stage ≥ 1) attended an inpatient rehabilitation program (intervention group, IG) for 23 ± 5 days. The CG (age 50 ± 12 years, 13 males and 17 females, 20 double LTxs, 2 BOS Stage ≥ 1) received medical standard therapy (physiotherapy). Patients were evaluated by cardiopulmonary exercise testing, 6-minute walk test (6MWT), SF-36, SGRQ and the Quality of Life Profile for Chronic Diseases questionnaire before and after (18 ± 3 days) the program. Results The groups were statistically indistinguishable in terms of clinical data. Each treatment group significantly improved their sub-maximal EC (6MWT: IG, 493 ± 90 m vs 538 ± 90 m, p < 0.001; CG, 490 ± 88 m vs 514 ± 89 m, p < 0.001) and maximal EC (VO(2peak): IG, 17.0 vs 18.5 ml/min/kg, p = 0.039; CG, 18.0 vs 19.5 ml/min/kg, p = 0.005), without reaching statistical significance between the groups. In both study groups, patients HRQOL tended to improve. Significant correlations were found between EC parameters and HRQOL scales. Conclusions Our data suggest that structured physical training may improve exercise tolerance in LTS. Our study results did not demonstrate a significant benefit of an inpatient over an outpatient exercise program.

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Metadata

Authors
Ihle, F., Neurohr, C., Huppmann, P., Zimmermann, G., Leuchte, H., Baumgartner, R., Kenn, K., Sczepanski, B., Hatz, R., Czerner, S., Frey, L., Ueberfuhr, P., Bittmann, I., & Behr, J.
Affiliations
LMU Klinikum (DE)
ORCID
Venue
The Journal of Heart and Lung Transplantation
Publisher
Elsevier BV
Published
2011-04
Volume
30
Issue
8
Pages
912-9
ISSN
1053-2498 (ISSN-L)
DOI
10.1016/j.healun.2011.02.006
OpenAlex
W2163447359
Cited by
50
References
32
Citations by year
2024: 2 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 7 · 2017: 1 · 2016: 7 · 2015: 5 · 2014: 3 · 2013: 6 · 2012: 1
FWCI
3.25
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Heart and Lung Transplantation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Medical Practices and Rehabilitation
Keywords
lung transplantation, inpatient rehabilitation, health-related quality of life, exercise capacity, long-term transplant survivors, 6-minute walk test, cardiopulmonary exercise testing, physiotherapy
MeSH terms
Adult, Female, Humans, Inpatients, Male, Middle Aged, Outpatients, Prospective Studies, Quality of Life, Surveys and Questionnaires, Respiratory Function Tests, Lung Transplantation, Walking, Treatment Outcome, Exercise Tolerance, Physical Therapy Modalities

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CoChat. (2026). Citation check: Effect of inpatient rehabilitation on quality of life and exercise capacity in long-term lung transplant survivors: A prospective, randomized study. https://app.cochat.ai/papers/10.1016/j.healun.2011.02.006
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Ihle, F., Neurohr, C., Huppmann, P., Zimmermann, G., Leuchte, H., Baumgartner, R., Kenn, K., Sczepanski, B., Hatz, R., Czerner, S., Frey, L., Ueberfuhr, P., Bittmann, I., & Behr, J. (2011). Effect of inpatient rehabilitation on quality of life and exercise capacity in long-term lung transplant survivors: A prospective, randomized study. The Journal of Heart and Lung Transplantation. https://doi.org/10.1016/j.healun.2011.02.006