The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Use of Pressure-volume Conductance Catheters in Real-time Cardiovascular Experimentation
Open accessAbstract
Background Most applications of pressure-volume conductance catheter measurements assess cardiovascular function at a single point in time after genetic, pharmacologic, infectious, nutritional, or toxicologic manipulation. Use of these catheters as a continuous monitor, however, is fraught with complexities and limitations. Methods Examples of the limitations and optimal use of conductance catheters as a continuous, real-time monitor of cardiovascular function are demonstrated during inotropic drug infusion in anesthetised rats. Results Inotropic drug infusion may alter ventricular dimensions causing relative movement of a well-positioned catheter, generating artifacts, including an abrupt pressure rise at end-systole that leads to over estimation of indices of contractility (max dP/dt) and loss of stroke volume signal. Simple rotation of the catheter, echocardiography-guided placement to the centre of the ventricle, or ventricular expansion through crystalloid infusion may correct for these artifacts. Fluid administration, however, alters left ventricular end-diastolic pressure and volume and therefore stroke volume, thereby obscuring continuous real-time haemodynamic measurements. Conclusions Pressure-volume artifacts during inotropic infusion are caused by physical contact of the catheter with endocardium. Repeated correction of catheter position may be required to use pressure volume catheters as a continuous real-time monitor during manipulations that alter ventricular dimensions, such as inotropic therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Wave reflection in the systemic circulation and its implications in ventricular function
O??Rourke, M. F., & Kelly, R. P. (1993) · Journal of Hypertension · doi:10.1097/00004872-199304000-00001 · Cited by 278 · cited 1×
“While these data attribute ESP artifact to contact of the catheter with the endocardium that can be easily eliminated, there are certain pathophysiological conditions that can also lead to legitimate, non-artifactual rises in ESP from reflected pressure waves [25, 26].”
Background
Flagged first, then by citations
Research works printed but not linked: 28
- Cingolani, 2011, Pressure-volume relation analysis of mouse ventricular function, Am J Physiol Heart Circ Physiol, 301, H2198, 10.1152/ajpheart.00781.2011 · DOI
- Klabunde RE. Cardiac Function: The Cardiac Cycle. Cardiovascular Physiology Concepts. 2nd edition. Edited by Crystal Taylor. Philadelphia: Lippincott Williams and Wilkins; 2012:62–7.
- Pacher, 2008, Measurement of cardiac function using pressure–volume conductance catheter technique in mice and rats, Nat Protoc, 3, 1422, 10.1038/nprot.2008.138 · DOI · Paper page
- Baan, 1984, Continuous measurement of left ventricular volume in animals and humans by conductance catheter, Circulation, 70, 812, 10.1161/01.CIR.70.5.812 · DOI
- Georgakopoulos, 1998, In vivo murine left ventricular pressure-volume relations by miniaturized conductance micromanometry, Am J Physiol Heart Circ Physiol, 274, H1416, 10.1152/ajpheart.1998.274.4.H1416 · DOI
- Pacher, 2004, Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure, Am J Physiol Heart Circ Physiol, 287, H2132, 10.1152/ajpheart.00405.2004 · DOI
- Shioura, 2007, Assessment of cardiac function with the pressure-volume conductance system following myocardial infarction in mice, Am J Physiol Heart Circ Physiol, 293, H2870, 10.1152/ajpheart.00585.2007 · DOI
- Tam, 2006, Enhanced vascular responses to adrenomedullin in mice overexpressing receptor-activity, Circ Res, 98, 262, 10.1161/01.RES.0000200737.63865.58 · DOI
- Wallis, 2005, Supranormal Myocardial Creatine and Phosphocreatine Concentrations Lead to Cardiac Hypertrophy and Heart Failure: Insights From Creatine Transporter, Circulation, 112, 3131, 10.1161/CIRCULATIONAHA.105.572990 · DOI
- Lovich, 2011, Local epicardial inotropic drug delivery allows targeted pharmacologic intervention with preservation of myocardial loading conditions, J Pharm Sci, 100, 4993, 10.1002/jps.22681 · DOI
- Maslov, 2013, High concentrations of drug in target tissues following local controlled release are utilized for both drug distribution and biologic effect: An example with epicardial inotropic drug delivery, J Control Release, 171, 201, 10.1016/j.jconrel.2013.06.038 · DOI
- Batkai, 2004, Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension, Circulation, 110, 1996, 10.1161/01.CIR.0000143230.23252.D2 · DOI
- Filipsky, 2012, Acute initial haemodynamic changes in a rat isoprenaline model of cardiotoxicity, Hum Exp Toxicol, 31, 830, 10.1177/0960327112438927 · DOI
- Ruffolo, 1987, The pharmacology of dobutamine, Am J Med Sci, 294, 244, 10.1097/00000441-198710000-00005 · DOI
- Sagawa, 1977, End-Systolic pressure/volume ratio: a new index of ventricular contractility, Am J Cardiol, 40, 748, 10.1016/0002-9149(77)90192-8 · DOI
- Montgomery, 2005, Protein kinase Ce induces systolic cardiac failure marked by exhausted inotropic reserve and intact Frank-Starling mechanism, Am J Physiol Heart Circ Physiol, 289, H1881, 10.1152/ajpheart.00454.2005 · DOI
- Nemoto, 2002, Effects of changes in left ventricular contractility on indexes of contractility in mice, Am J Physiol Heart Circ Physiol, 283, H2504, 10.1152/ajpheart.0765.2001 · DOI
- Suga, 1979, End-systolic pressure determines stroke volume from fixed end-diastolic volume in the isolated canine left ventricle under a constant contractile state, Circ Res, 44, 238, 10.1161/01.RES.44.2.238 · DOI
- Toa, 2004, β2-Microglobulin knockout mice treated with anti-asialoGM1 exhibit improved hemodynamics and cardiac contractile function during acute intra-abdominal sepsis, Am J Physiol Regul Integr Comp Physiol, 286, R569, 10.1152/ajpregu.00470.2003 · DOI
- Van den Bergh, 2008, Parameters of ventricular contractility in mice: influence of load and sensitivity to changes in inotropic state, Pflugers Arch, 455, 987, 10.1007/s00424-007-0362-8 · DOI
- Zhao, 2011, Arterial Pressure Monitoring in Mice, Curr Protoc Mouse Biol, 1, 105, 10.1002/9780470942390.mo100149 · DOI
- Fischer, 1988, Detection of left ventricular regional myocardial ischaemia in dogs by intraventricular conductance catheter, Cardiovasc Res, 22, 185, 10.1093/cvr/22.3.185 · DOI
- Khoury, 1989, Continuous right ventricular volume assessment by catheter measurement of impedance for antitachycardia system control, Pacing Clin Electrophysiol., 12, 1918, 10.1111/j.1540-8159.1989.tb01885.x · DOI
- Sugai, 2010, Estimation of maximum ventricular elastance under assistance with a rotary blood pump, Artif Organs., 34, 442, 10.1111/j.1525-1594.2009.00876.x · DOI
- Karamanoglu, 1999, Late systolic pressure augmentation: role of left ventricular outflow patterns, Am J Physiol, 277, H481
- Kelly, 1989, Noninvasive determination of age-related changes in the human arterial pulse, Circulation., 80, 1652, 10.1161/01.CIR.80.6.1652 · DOI
- Marchais, 1993, Wave reflections and cardiac hypertrophy in chronic uremia. Influence of body size, Hypertension, 22, 876, 10.1161/01.HYP.22.6.876 · DOI
- O’Rourke, 1990, Arterial stiffness, systolic blood pressure, and logical treatment of arterial hypertension, Hypertension, 15, 339, 10.1161/01.HYP.15.4.339 · DOI
Cited by
Sorted by citations
A human engineered mini-heart platform for mimicking ventricular pump function
Ribeiro, M. C., Cano-Jorge, M., ten Den, S., Snippert, D., Karperien, M., Kamperman, T., Lajoinie, G., Versluis, M., & Passier, R. (2025) · bioRxiv · doi:10.1101/2025.08.25.672056 · Cited by 1
Metadata
- Authors
- Wei, A. E., Maslov, M. Y., Pezone, M. J., Edelman, E. R., & Lovich, M. A.
- Affiliations
- Tufts University (US)
- Harvard–MIT Division of Health Sciences and Technology (US)
- Corresponding author
- Maslov, Mikhail Y.
- ORCID
- Edelman, Elazer R.
- Venue
- Heart, Lung and Circulation
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 23
- Issue
- 11
- Pages
- 1059-1069
- ISSN
- 1443-9506 (ISSN-L)
- PMC
- PMC4241179
- OpenAlex
- W1980457082
- Cited by
- 17
- References
- 1
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 3 · 2015: 1
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Heart Lung and Circulation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
- PMC
- Funders
- American Heart Association (09SDG2060320)
- Massachusetts Institute of Technology
- National Institutes of Health (NIH-R01, GM 49039)
- Deshpande Center for Technological Innovation, Massachusetts Institute of Technology
- National Institute of General Medical Sciences (R01-GM-49039, R01GM049039)
- Topics
- Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- ventricular size, left ventricular contractility, stroke volume, left ventricular end-diastolic pressure, catheter positioning, crystalloid infusion, fluid administration
- MeSH terms
- Animals, Cardiotonic Agents, Cardiac Catheterization, Heart Ventricles, Hemodynamics, Male, Myocardial Contraction, Ventricular Function, Rats, Sprague-Dawley, Rats, Cardiac Catheters
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
