Serum adropin level in patients with stable coronary artery disease
Abstract
Objectives Adropin is a newly identified secreted protein implicated in the regulation of insulin sensitivity and vascular endothelial function. Recent studies have shown that lower serum adropin level is related to acute myocardial infarction and coronary atherosclerosis. The primary objective of this study was to ascertain the association of serum adropin level with stable coronary artery disease (SCAD). Methods We prospectively recruited a cohort of patients with SCAD and similar sample size subjects without coronary artery disease as controls. Their serum adropin levels were measured, and the severity of coronary atherosclerosis in SCAD patients was quantified with the syntax score. Results A total of 116 patients with SCAD and 116 control subjects without coronary artery disease were recruited. Patients with SCAD had lower serum adropin levels when compared with the controls (59.2±19.3 versus 70.0±18.2 pg/mL, P Conclusions Low serum adropin level is a significant predictor of SCAD. It is also associated with syntax score, thus indicating the close relationship between adropin and coronary atherosclerosis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In patients undergoing coronary artery bypass graft surgery, the lowest level of plasma adropin was associated with late saphenous vein graft occlusion.
“A recent study of patients undergoing coronary artery bypass graft surgery showed that the lowest level of plasma adropin was associated with late saphenous vein graft occlusion.”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [81]
Adropin affects the progression of vascular atherosclerosis.
“Thus, it ended up providing evidence that adropin affected the progression of vascular atherosclerosis [81].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [81]
Adropin is a biomarker of cardiovascular dysfunction.
“Still, in this respect, there is increasing evidence that adropin is a biomarker of cardiovascular dysfunction, initially because in vitro tests showed that endothelial cells treated with adropin had greater proliferation, migration, formation of a capillary-like tube, and positive regulation of the expression of nitric oxide endothelial synthase (eNOS).”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [81]
The citation lists haven’t been fetched yet
References 33 · Cited by 46
- Authors
- Zhao, L.-P., Xu, W.-T., Wang, L., You, T., Chan, S.-P., Zhao, X., & Yang, X.-J.
- Affiliations
- Second Affiliated Hospital of Soochow University (CN)
- National University of Singapore (SG)
- First Affiliated Hospital of Soochow University (CN)
- Venue
- Heart Lung and Circulation
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 24
- Issue
- 10
- Pages
- 975-979
- ISSN
- 1443-9506 (ISSN-L)
- OpenAlex
- W1994410804
- Cited by
- 46
- References
- 33
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 5 · 2015: 1
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Heart Lung and Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Pharmacology › Apelin-related biomedical research
- Keywords
- adropin, stable coronary artery disease, coronary artery disease, SYNTAX score, serum biomarkers, insulin sensitivity, endothelial function, risk prediction
- MeSH terms
- Aged, Blood Proteins, Coronary Artery Disease, Creatinine, Female, Humans, Insulin Resistance, Cholesterol, HDL, Male, Middle Aged, Peptides, Prospective Studies, Severity of Illness Index, Case-Control Studies, Intercellular Signaling Peptides and Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
