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Cited by 25Complementary and Alternative Medicine StudiesAsthma and respiratory diseasesMast cells and histamine

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Anti-asthmatic and anti-anaphylactic activities of Blatta orientalis mother tincture

Chandrakant Nimgulkar, Chetan, Dattatray Patil, Savita, Dinesh Kumar, B.·2011·Homeopathy
DOI 10.1016/j.homp.2010.08.006
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Abstract

Objectives To study the anti-asthmatic and anti-anaphylactic activities of Blatta orientalis mother tincture (B. orientalis MT), a homeopathic medicine, in experimental animal models. Methods The anti-asthmatic activity of B. orientalis MT was studied in the bronchial hyperactivity models, acetylcholine and histamine induced bronchospasm, in guinea pigs. Anti-anaphylactic activity was tested by active and passive anaphylaxis models in rats, anti-eosinophilic activity was tested by milk-induced eosinophilia in mice. Results Significant protection against acetylcholine and histamine aerosol-induced bronchospasm in B. orientalis MT treated guinea pigs was seen. In active and passive anaphylaxis albino rat models significant reduction in mesenteric mast cells degranulation, serum IgE level and eosinophil cell count was observed in the B. orientalis MT treated rat group when compared with the sensitized control rat group. Conclusion These results reveal broad activity of B. orientalis MT. It may have nonselective anti-asthmatic activity. The anti-anaphylactic activity of B. orientalis MT may be due to mast cell stabilization, suppression of IgE and eosinophil cell count.

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Metadata

Authors
Chandrakant Nimgulkar, C., Dattatray Patil, S., & Dinesh Kumar, B.
Venue
Homeopathy
Publisher
Georg Thieme Verlag KG
Published
2011-07
Volume
100
Issue
3
Pages
138-143
ISSN
1475-4916 (ISSN-L)
DOI
10.1016/j.homp.2010.08.006
OpenAlex
W2139119122
Cited by
25
References
27
Citations by year
2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
2.56
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Homeopathy (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Keywords
antiasthmatic activity, anti-anaphylactic activity, bronchospasm, histamine-induced bronchoconstriction, active anaphylaxis, passive anaphylaxis, mast cell degranulation, IgE, eosinophilia, mast cell stabilization
MeSH terms
Analysis of Variance, Anaphylaxis, Animals, Bronchial Spasm, Bronchodilator Agents, Cockroaches, Disease Models, Animal, Dose-Response Relationship, Drug, Guinea Pigs, Histamine Release, Homeopathy, Pulmonary Eosinophilia, Bronchial Hyperreactivity, Rats, Wistar, Mice, Rats

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CoChat. (2026). Citation check: Anti-asthmatic and anti-anaphylactic activities of Blatta orientalis mother tincture. https://app.cochat.ai/papers/10.1016/j.homp.2010.08.006
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Chandrakant Nimgulkar, C., Dattatray Patil, S., & Dinesh Kumar, B. (2011). Anti-asthmatic and anti-anaphylactic activities of Blatta orientalis mother tincture. Homeopathy. https://doi.org/10.1016/j.homp.2010.08.006

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