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Immunohistochemical expression of folate receptor α in colorectal carcinoma: patterns and biological significance

Shia, Jinru, Klimstra, David S., Nitzkorski, James R., Low, Philip S., Gonen, Mithat, Landmann, Ron, Weiser, Martin R., Franklin, Wilbur A., Prendergast, Franklyn G., Murphy, Linda, Tang, Laura H., Temple, Larissa, Guillem, Jose G., Wong, W. Douglas, Paty, Philip B.·2008·Human Pathology
DOI 10.1016/j.humpath.2007.09.013
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Abstract

Folate receptor alpha (FRalpha) has emerged as a potential cancer therapy target with several folate-linked therapeutic agents currently undergoing clinical trials. In addition, FRalpha expression in tumors may offer prognostic significance. Most studies on FRalpha expression used reverse transcriptase polymerase chain reaction or cytofluorimetric assays. The applicability of such methods to paraffin-embedded tissues is limited. The aims of this study were to assess the feasibility of immunohistochemistry in detecting FRalpha expression and to assess the patterns and clinical significance of FRalpha expression in colorectal tissues. We used tissue microarrays containing 152 normal colorectal mucosa samples, 42 adenomas, 177 primary, and 52 metastatic colorectal carcinomas. Our results showed that staining for FRalpha on colorectal tissues was simple and easy to read. FRalpha positivity was more frequent in carcinomas (33% in primaries and 44% in metastases) than in normal mucosa or adenoma (7% in both) (P < .001). Positive staining in primary carcinomas correlated with younger age (n = 130) (P = .008), presence of distant metastasis (n = 130) (P = .043), and non-high-frequency microsatellite instability status (as detected by the standard polymerase chain reaction method using the 5 National Cancer Institute-recommended markers) (n = 77) (P = .006). Positive staining in primary carcinomas also correlated with a worse 5-year disease-specific survival (P = .04) on univariate bu…

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Research works printed but not linked: 38

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Metadata

Authors
Shia, J., Klimstra, D. S., Nitzkorski, J. R., Low, P. S., Gonen, M., Landmann, R., Weiser, M. R., Franklin, W. A., Prendergast, F. G., Murphy, L., Tang, L. H., Temple, L., Guillem, J. G., Wong, W. D., & Paty, P. B.
Venue
Human Pathology
Publisher
Elsevier BV
Published
2008-04
Volume
39
Issue
4
Pages
498-505
ISSN
0046-8177
DOI
10.1016/j.humpath.2007.09.013
Cited by
106
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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