The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Prevalence of tumor-infiltrating lymphocytes and PD-L1 expression in the soft tissue sarcoma microenvironment
Open accessAbstract
The prognostic and predictive implications of programmed death-ligand 1 (PD-L1) is unknown in sarcoma. We sought to examine the immune milieu in sarcoma specimens. We evaluated PD-L1 expression by immunohistochemistry (IHC) in sarcoma specimens and quantified tumor infiltrating lymphocytes (TIL). We correlated expression with clinical parameters and outcomes. Fifty sarcoma patients treated at Memorial Sloan Kettering Cancer Center were selected. Using the DAKO PD-L1 IHC assay and archival formalin-fixed paraffin embedded tissue specimens; PD-L1 expression was examined. Macrophage and lymphocyte PD-L1 status was determined qualitatively. TIL was quantified. Associations between PD-L1 expression in tumor, macrophages and lymphocytes, TIL and clinical-pathological characteristics were performed. The median age was 46 years (range, 22 – 76) and 66% of patients were male. Tumor, lymphocyte and macrophage PD-L1 expression was noted in 12%, 30% and 58%, respectively with the highest prevalence in gastrointestinal stromal tumors (GIST) (29%.) Lymphocyte and macrophage infiltration was present in 98% and 90%, respectively. There was no association between clinical features, overall survival and PD-L1 expression in tumor or immune infiltrates. Lymphocyte and macrophage infiltration is common in sarcoma, but PD-L1 tumor expression is uncommon in sarcoma with the highest frequency observed in GIST. There was no association between PD-L1 expression, TIL and clinicopathological features and overall survival, however this is limited by the heterogenous patient sample and minimal death events in the studied cohort.
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Cites
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
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Self-citationTumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
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B cells are associated with survival and immunotherapy response in sarcoma
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Self-citationPD-L1 expression in human cancers and its association with clinical outcomes
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D'Angelo, S. P., Mahoney, M. R., Van Tine, B. A., Atkins, J., Milhem, M. M., Jahagirdar, B. N., Antonescu, C. R., Horvath, E., Tap, W. D., Schwartz, G. K., et al. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30006-8 · Cited by 759
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Metadata
- Authors
- D’Angelo, S. P., Shoushtari, A. N., Agaram, N. P., Kuk, D., Qin, L.-X., Carvajal, R. D., Dickson, M. A., Gounder, M., Keohan, M. L., Schwartz, G. K., & Tap, W. D.
- Venue
- Human Pathology
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 46
- Issue
- 3
- Pages
- 357-365
- ISSN
- 0046-8177 (ISSN-L)
- OpenAlex
- W2081070412
- Cited by
- 301
- References
- 30
- FWCI
- 15.02
- Type
- journal article
- Language
- en
- Open access
- green
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- D’Angelo, S. P., Shoushtari, A. N., Agaram, N. P., Kuk, D., Qin, L.-X., Carvajal, R. D., Dickson, M. A., Gounder, M., Keohan, M. L., Schwartz, G. K., & Tap, W. D. (2015). Prevalence of tumor-infiltrating lymphocytes and PD-L1 expression in the soft tissue sarcoma microenvironment. Human Pathology. https://doi.org/10.1016/j.humpath.2014.11.001
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