Fungal infections in the ICU
Abstract
Pulmonologists and intensivists often care for patients at risk for infections caused by both Aspergillus and Candida. Infection with either can lead to severe life-threatening disease, particularly in immunosuppressed patients, with mortality rates for invasive fungal disease often exceeding 30%. For both organisms, multiple diagnostic challenges remain while newer diagnostic modalities are being developed and tested. Fortunately, therapeutic paradigms are shifting, and clinicians have many new agents in their armamentarium for combating fungal infection. Given the rapidly changing literature in this broad area, it is imperative that physicians caring for immunosuppressed patients and for the critically ill remain abreast of this evolving field.
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The gold standard diagnostic test for invasive candidiasis has been isolation of the organism in blood culture, but blood culture for Candida is insensitive.
“In addition, the gold standard diagnostic test for IC has been isolation of the organism in blood culture, however, blood culture for Candida is insensitive.[52][53][54][55]”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [53]
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References 84 · Cited by 42
- Authors
- Zilberberg, M. D., & Shorr, A. F.
- Affiliations
- University of Massachusetts Amherst (US)
- MedStar Washington Hospital Center (US)
- Corresponding author
- Zilberberg, Marya D.
- Venue
- Infectious Disease Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 23
- Issue
- 3
- Pages
- 625-642
- ISSN
- 0891-5520 (ISSN-L)
- OpenAlex
- W2012665468
- Cited by
- 42
- References
- 84
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2020: 1 · 2018: 1 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 6
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Infectious Disease Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- invasive fungal infections, Aspergillus, Candida, immunocompromised patients, critically ill patients, intensive care unit, diagnostic challenges, antifungal therapy, mortality
- MeSH terms
- Candidiasis, Cross Infection, Humans, Intensive Care Units, Pulmonary Aspergillosis
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