Cited by 1Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismAcute Myocardial Infarction Research

Efficacy and safety of add on Bempedoic acid on maximal dose of Rosuvastatin and Ezetimibe in patients with established coronary artery disease

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Jaiswal, Amit, Garg, Naveen, Kapoor, Aditya, Tewari, Satyendra, Kumar, Sudeep, Khanna, Roopali, Sahu, Ankit, Khare, Harshit +2 more·2024·Indian Heart Journal

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Crossref · 10.1016/j.ihj.2024.11.211

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  • In two studies of patients with ASCVD on maximum dose rosuvastatin plus ezetimibe or rosuvastatin/atorvastatin plus ezetimibe, initiation of bempedoic acid achieved LDL-C reductions of 29.1% to 39.0% at 6 months.

    “In these studies, the initiation of bempedoic acid achieved LDL-C reductions of 29.1% (baseline LDL-C = 100 mg/dL) to 39.0% (baseline LDL-C = 130 mg/dL) at 6 months’ follow-up [32,38].”
  • Real-world LDL-C reductions with bempedoic acid in secondary prevention populations ranged from 15% to 39%.

    “These reductions were reported across both primary (23% to 39%) [24,29,44] and secondary prevention populations (15% to 39%) [25,32,38,39].”
  • LDL-C reductions with bempedoic acid added to statins ranged from 15% to 39%.

    “Consistent effects were also seen when bempedoic acid was added to statins (15% to 39%) [25,30,32,38,39,44], and when used in statin intolerant patients (22% to 38%) [24,29,34,35,37,40,41], despite the latter group having higher baseline LDL-C.”

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Authors
Jaiswal, A., Garg, N., Kapoor, A., Tewari, S., Kumar, S., Khanna, R., Sahu, A., Khare, H., Katharia, A., & Arshad
Affiliations
Sanjay Gandhi Post Graduate Institute of Medical Sciences (IN)
Venue
Indian Heart Journal
Publisher
Elsevier BV
Published
2024-12
Volume
76
Pages
S109
ISSN
0019-4832 (ISSN-L)
OpenAlex
W4405082174
Cited by
0
References
0
FWCI
0.00
Type
journal article
Language
en
Open access
Locations
Indian Heart Journal (publishedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Keywords
bempedoic acid, rosuvastatin, ezetimibe, adjunctive therapy, coronary artery disease, lipid-lowering therapy, LDL cholesterol lowering

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