Efficacy and safety of add on Bempedoic acid on maximal dose of Rosuvastatin and Ezetimibe in patients with established coronary artery disease
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In two studies of patients with ASCVD on maximum dose rosuvastatin plus ezetimibe or rosuvastatin/atorvastatin plus ezetimibe, initiation of bempedoic acid achieved LDL-C reductions of 29.1% to 39.0% at 6 months.
“In these studies, the initiation of bempedoic acid achieved LDL-C reductions of 29.1% (baseline LDL-C = 100 mg/dL) to 39.0% (baseline LDL-C = 130 mg/dL) at 6 months’ follow-up [32,38].”
From Systematic literature review on the real-world effectiveness and safety of bempedoic acid (2026) · cites this paper as [38]
Real-world LDL-C reductions with bempedoic acid in secondary prevention populations ranged from 15% to 39%.
“These reductions were reported across both primary (23% to 39%) [24,29,44] and secondary prevention populations (15% to 39%) [25,32,38,39].”
From Systematic literature review on the real-world effectiveness and safety of bempedoic acid (2026) · cites this paper as [38]
LDL-C reductions with bempedoic acid added to statins ranged from 15% to 39%.
“Consistent effects were also seen when bempedoic acid was added to statins (15% to 39%) [25,30,32,38,39,44], and when used in statin intolerant patients (22% to 38%) [24,29,34,35,37,40,41], despite the latter group having higher baseline LDL-C.”
From Systematic literature review on the real-world effectiveness and safety of bempedoic acid (2026) · cites this paper as [38]
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Systematic literature review on the real-world effectiveness and safety of bempedoic acid
Cicero, A. F. G., Cannon, C. P., Gautam, R., Anwar, S., Ghatak, A., Sarnes, E., Powell, H. A., Chhabra, R., & Jawla, S. (2026) · Atherosclerosis Plus · doi:10.1016/j.athplu.2026.100562 · Cited by 1 · see citing works
- Authors
- Jaiswal, A., Garg, N., Kapoor, A., Tewari, S., Kumar, S., Khanna, R., Sahu, A., Khare, H., Katharia, A., & Arshad
- Affiliations
- Sanjay Gandhi Post Graduate Institute of Medical Sciences (IN)
- Venue
- Indian Heart Journal
- Publisher
- Elsevier BV
- Published
- 2024-12
- Volume
- 76
- Pages
- S109
- ISSN
- 0019-4832 (ISSN-L)
- OpenAlex
- W4405082174
- Cited by
- 0
- References
- 0
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Indian Heart Journal (publishedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- bempedoic acid, rosuvastatin, ezetimibe, adjunctive therapy, coronary artery disease, lipid-lowering therapy, LDL cholesterol lowering
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