Chemotherapeutic efficacy of poly (dl-lactide-co-glycolide) nanoparticle encapsulated antitubercular drugs at sub-therapeutic dose against experimental tuberculosis
Abstract
The present study was designed to evaluate the chemotherapeutic efficacy of poly (DL-lactide-co-glycolide) (PLG) nanoparticles (NP) encapsulating three front-line antitubercular drugs (ATDs: rifampicin, RIF; isoniazid, INH and pyrazinamide, PZA) at 2/3rd therapeutic dose. PLG nanoparticles prepared by the double emulsion and solvent evaporation technique were administered orally at 2/3rd therapeutic dose to guinea pigs. A single oral administration of the formulation resulted in sustained drug levels in the plasma for 7-12 days and in the organs for 11-14 days with a significant improvement in mean residence time as well as drug bioavailability. The administration of PLG nanoparticles every 10 days (five doses) to Mycobacterium tuberculosis H(37)Rv infected guinea pigs led to undetectable bacilli in the organs, as did 46 conventional doses. Therefore, nanoparticle based antitubercular chemotherapy forms a sound basis for a reduction in dosing frequency and also offers the possibility of reducing the drug dosage.
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Polymer-based nanoparticles (PLGA and sodium alginate) have been developed to improve the oral bioavailability of rifampicin, isoniazid, ethambutol, pyrazinamide and streptomycin.
“Polymer-based nanoparticles (PLGA and sodium alginate) have also been developed to improve the oral bioavailability of rifampicin, isoniazid, ethambutol, pyrazinamide and streptomycin 124-127 .”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [127]
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References 20 · Cited by 111
- Authors
- Sharma, A., Pandey, R., Sharma, S., & Khuller, G. K.
- Affiliations
- Post Graduate Institute of Medical Education and Research (IN)
- Corresponding author
- Khuller, G.K.
- Venue
- International Journal of Antimicrobial Agents
- Publisher
- Elsevier BV
- Published
- 2004-12
- Volume
- 24
- Issue
- 6
- Pages
- 599-604
- ISSN
- 0924-8579 (ISSN-L)
- OpenAlex
- W2031190569
- Cited by
- 111
- References
- 20
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 6 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 6 · 2015: 5 · 2014: 11 · 2013: 6 · 2012: 8
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Antimicrobial Agents (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Keywords
- antitubercular agents, tuberculosis, rifampicin, isoniazid, pyrazinamide, drug encapsulation, sustained drug release, oral drug delivery, Mycobacterium tuberculosis H37Rv, guinea pig model, drug bioavailability, reduced dosing frequency
- MeSH terms
- Polylactic Acid-Polyglycolic Acid Copolymer, Administration, Oral, Animals, Antitubercular Agents, Biological Availability, Chemistry, Physical, Drug Carriers, Drug Compounding, Drug Therapy, Guinea Pigs, Mycobacterium tuberculosis, Polyglycolic Acid, Polymers, Tuberculosis, Drug Delivery Systems, Lactic Acid, Chemical Phenomena
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