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Molecular epidemiology of Escherichia coli producing CTX-M β-lactamases: the worldwide emergence of clone ST131 O25:H4
Abstract
Since 2000, Escherichia coli producing CTX-M enzymes have emerged worldwide as important causes of community-onset urinary tract and bloodstream infections owing to extended-spectrum beta-lactamase (ESBL)-producing bacteria. Molecular epidemiological studies suggested that the sudden worldwide increase of CTX-M-15-producing E. coli was mainly due to a single clone (ST131) and that foreign travel to high-risk areas, such as the Indian subcontinent, might in part play a role in the spread of this clone across different continents. Empirical antibiotic coverage for these resistant organisms should be considered in community patients presenting with sepsis involving the urinary tract, especially if the patient recently travelled to a high-risk area. If this emerging public health threat is ignored, it is possible that the medical community may be forced, in the near future, to use carbapenems as the first choice for the empirical treatment of serious infections associated with urinary tract infections originating from the community.
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“The molecular epidemiology of the ESBL-E enzymes identified in the Madagascar (Chereau et al., 2015), Nigeria (Fortini et al., 2015), Cameroon (Djuikoue et al., 2016b), and Mozambique (Sáez-lópez et al., 2016) studies was in keeping with the global predominance of the CTX-M clone, which is also widely reported in community-acquired UTI (Pitout et al., 2005;Peirano and Pitout, 2010;Pallecchi et al.”
From Maternal colonization or infection with extended-spectrum beta-lactamase-producing Enterobacteriaceae in Africa: A systematic review and meta-analysis (2017) · cites this paper as Peirano and Pitout, 2010
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Metadata
- Authors
- Peirano, G., & Pitout, J. D. D.
- Affiliations
- University of Calgary (CA)
- ORCID
- Pitout, Johann D.D.
- Venue
- International Journal of Antimicrobial Agents
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 35
- Issue
- 4
- Pages
- 316-321
- ISSN
- 0924-8579 (ISSN-L)
- OpenAlex
- W2087341525
- Cited by
- 443
- References
- 89
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 17 · 2023: 19 · 2022: 14 · 2021: 15 · 2020: 18 · 2019: 28 · 2018: 20 · 2017: 18 · 2016: 39 · 2015: 35 · 2014: 49 · 2013: 52 · 2012: 56
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Antimicrobial Agents (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
- Health Sciences › Medicine › Urology › Urinary Tract Infections Management
- Keywords
- Escherichia coli, CTX-M, ST131, extended-spectrum beta-lactamase, molecular epidemiology, antimicrobial resistance, urinary tract infection, bloodstream infection, sepsis, international travel, Indian subcontinent, empirical antibiotic therapy, carbapenems
- MeSH terms
- Anti-Bacterial Agents, beta-Lactamases, Disease Outbreaks, Escherichia coli, Escherichia coli Infections, Humans, Travel, Urinary Tract Infections, Bacterial Typing Techniques, Bacteremia, Molecular Epidemiology, Escherichia coli Proteins
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