The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Changes in denaturation and rheological properties of collagen–hyaluronic acid scaffolds as a result of temperature dependencies
Abstract
This report describes the effect of temperature on the mechanical viscoelastic properties such as: storage modulus (E'), loss modulus (E''), and loss tangent (tandelta) of the collagen sponges modified with hyaluronic acid (HA). In order to detect collagen-HA copolymer denaturation and to assess its thermal stability, the differential scanning calorimetry (DSC) supplemented by thermogravimetric (TG) measurements was used. The denaturation temperature (T(d)) of unmodified collagen samples increased from 69 to 86 degrees C for cross-linked samples, respectively. These temperature dependencies show remarkable changes in E' and E'' at selected temperature up to 226 degrees C for all samples due to the release of loosely and strongly bound water. The influence of HA on the viscoelastic behavior of collagen is manifested by a shift of the tandelta peak associated with the process of decomposition towards higher temperatures resulting in a higher thermo-stability of the modified scaffolds.
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“The second endothermic transition observed at higher temperature corresponds to extensive conformational rearrangements and disruption of residual intermolecular interactions within the collagen matrix, representing an advanced stage of structural destabilization under thermal stimulus, as previously reported by Pietrucha, 2005 [41].”
Citations
Cites
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Research works printed but not linked: 4
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Cited by
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Antunes, B. S. L., Pedrini, F., Komatsu, D., Asami, J., Dicko, C., & Duek, E. A. R. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.154129
Metadata
- Authors
- Pietrucha, K.
- Affiliations
- Lodz University of Technology (PL)
- Corresponding author
- Pietrucha, Krystyna
- ORCID
- Pietrucha, Krystyna
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 36
- Issue
- 5
- Pages
- 299-304
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W2091139873
- Cited by
- 142
- References
- 26
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 9 · 2021: 8 · 2020: 6 · 2019: 8 · 2018: 10 · 2017: 8 · 2016: 9 · 2015: 10 · 2014: 10 · 2013: 13 · 2012: 8
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Keywords
- collagen, hyaluronic acid, collagen sponge, denaturation temperature, thermal stability, viscoelasticity, storage modulus, loss modulus, loss tangent, crosslinking, water release, biomaterial scaffolds
- MeSH terms
- Animals, Biophysics, Calorimetry, Differential Scanning, Cross-Linking Reagents, Hot Temperature, Hyaluronic Acid, Models, Chemical, Molecular Conformation, Pepsin A, Polymers, Swine, Temperature, Tendons, Thermogravimetry, Water, Collagen Type I, Macromolecular Substances, Biophysical Phenomena
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