Highly porous of hydroxyethyl cellulose biocomposite scaffolds for tissue engineering
Abstract
This study is focusing to develop a porous biocompatible scaffold using hydroxyethyl cellulose (HEC) and poly (vinyl alcohol) (PVA) with improved cellular adhesion profiles and stability. The combination of HEC and PVA were synthesized using freeze-drying technique and characterized using SEM, ATR-FTIR, TGA, DSC, and UTM. Pore size of HEC/PVA (2-40 μm) scaffolds showed diameter in a range of both pure HEC (2-20 μm) and PVA (14-70 μm). All scaffolds revealed high porosity above 85%. The water uptake of HEC was controlled by PVA cooperation in the polymer matrix. After 7 days, all blended scaffolds showed low degradation rate with the increased of PVA composition. The FTIR and TGA results explicit possible chemical interactions and mass loss of blended scaffolds, respectively. The T g values of DSC curved in range of HEC and PVA represented the miscibility of HEC/PVA blend polymers. Higher Young's modulus was obtained with the increasing of HEC value. Cell-scaffolds interaction demonstrated that human fibroblast (hFB) cells adhered to polymer matrices with better cell proliferation observed after 7 days of cultivation. These results suggested that biocompatible of HEC/PVA scaffolds fabricated by freeze-drying method might be suitable for skin tissue engineering applications.
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PVA-based scaffold design with >85% is favorable for tissue engineering applications.
“PVA-based scaffold design with >85% is favorable for the TE applications [14].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [14]
The rate of polymer degradation can be modulated by adjusting the composition, molecular weight, and end groups in the polymer, as well as by the composition and geometry of the device.
“The rate of degradation can be modulated by adjusting the composition, molecular weight, and end groups in the polymer, as well as by the composition and geometry of the device [14].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [14]
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Cellulose-based composite scaffolds for bone tissue engineering and localized drug delivery
Janmohammadi, M., Nazemi, Z., Salehi, A. O. M., Seyfoori, A., John, J. V., Nourbakhsh, M. S., & Akbari, M. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.05.018 · Cited by 323 · see citing works
Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review
Vach Agocsova, S., Culenova, M., Birova, I., Omanikova, L., Moncmanova, B., Danisovic, L., Ziaran, S., Bakos, D., & Alexy, P. (2023) · Materials · doi:10.3390/ma16124267 · Cited by 98 · see citing works
- Authors
- Zulkifli, F. H., Hussain, F. S. J., Harun, W. S. W., & Yusoff, M. M.
- Affiliations
- Universiti Malaysia Pahang Al-Sultan Abdullah (MY)
- Corresponding author
- Zulkifli, Farah Hanani
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 122
- Pages
- 562-571
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W2897075578
- Cited by
- 62
- References
- 0
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 7 · 2023: 12 · 2022: 10 · 2021: 7 · 2020: 12 · 2019: 4
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- UMP Institutional Repository (Universiti Malaysia Pahang) (acceptedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- hydroxyethyl cellulose, polyvinyl alcohol, porous scaffolds, freeze-drying, polymer blends, porosity, water absorption, degradation rate, thermal stability, glass transition, mechanical properties, human fibroblasts, cell adhesion, skin tissue engineering, biocomposites
- MeSH terms
- Biocompatible Materials, Cellulose, Fibroblasts, Humans, Porosity, Tissue Engineering, Tissue Scaffolds, Mechanical Phenomena
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