Polysaccharide from Spirulina platensis ameliorates diphenoxylate-induced constipation symptoms in mice
Abstract
The aim of this study is to probe new functions of a polysaccharide from Spirulina platensis (PSP) on constipation and intestinal microbiota in mice. Diphenoxylate-induced constipation in mice was treated with different doses of PSP, followed by examining the defecation patterns, levels of acetyl cholinesterase (AchE), nitric oxide (NO), and tissue section histopathology. The composition of intestinal microbiota was determined by genome sequencing analysis of the 16S rDNA. This study found that the average molecular weight of PSP was 29, 600 Da, and mainly monosaccharides of PSP were rhamnose (24.7%), glucose (16.15%) and galactose (13.32%). The beneficial effects of PSP treatment include defecation improvement, increase of AchE activity, reduction of NO concentration, renovation of the damaged intestinal villus and affection on the expression of some related genes in the constipated mice. In addition, PSP had significant effects on the gut microbiota, showing the enhancement in abundance of beneficial bacteria including Akkermansia, Lactobacillus, Butyricimonas, Candidatus Arthromitus and Prevotella, and the reduction in abundance of harmful bacteria such as Clostridium and Dorea. The present s uncovered a new function of PSP, indicating that PSP could be used in constipation therapies.
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The composition of Arthrospira and the health benefits associated with consuming Arthrospira indicate that it has the potential to become a significant food and to be employed as an ingredient in the development of functional foods in the future.
“The composition of Arthrospira, as well as the health benefits associated with consuming Arthrospira (or compounds derived from it), indicate that it has the potential to become a significant food and to be employed as an ingredient in the development of functional foods in the future [19,20,86].”
From Challenges in Functional Food Products with the Incorporation of Some Microalgae (2024) · cites this paper as [86]
Several microalgae, such as Arthrospira platensis, Chlorella vulgaris, and Dunaliella bardawil, are examples of GRAS-approved microalgae.
“Several microalgae, such as Arthrospira platensis, Chlorella vulgaris, and Dunaliella bardawil, are examples of GRAS-approved microalgae [19,20,86].”
From Challenges in Functional Food Products with the Incorporation of Some Microalgae (2024) · cites this paper as [86]
Dried Arthrospira biomass has significantly lower values of bioactive compounds than freshly harvested biomass.
“Additionally, the dried Arthrospira biomass included significantly lower values of bioactive compounds than those of freshly harvested biomass [86,136].”
From Challenges in Functional Food Products with the Incorporation of Some Microalgae (2024) · cites this paper as [86]
Drying techniques are a key challenge that substantially impacts dried microalgal biomass.
“The drying techniques (e.g., solar drying, air drying, vacuum drying, free drying, and spray drying) are another key challenge that has a substantial impact on the dried microalgal biomass [86].”
From Challenges in Functional Food Products with the Incorporation of Some Microalgae (2024) · cites this paper as [86]
Drying techniques can severely deplete nutrients of microalgae.
“Drying techniques can severely deplete the nutrients of microalgae.”
From Challenges in Functional Food Products with the Incorporation of Some Microalgae (2024) · cites this paper as [86]
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References 57 · Cited by 100
- Authors
- Ma, H., Xiong, H., Zhu, X., Ji, C., Xue, J., Li, R., Ge, B., & Cui, H.
- Affiliations
- Shanxi Agricultural University (CN)
- China University of Petroleum, East China (CN)
- Corresponding author
- Li, Runzhi
- Ge, Baosheng
- Cui, Hongli
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 133
- Pages
- 1090-1101
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W2942688146
- Cited by
- 100
- References
- 57
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 16 · 2023: 19 · 2022: 11 · 2021: 24 · 2020: 9
- FWCI
- 10.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National key Research and Development Plan of China (2016YFE0106700)
- China Postdoctoral Science Foundation (2018M631768)
- State Ministry of Agriculture (2014-Z39)
- Shanxi Province Key Projects of Coal-based Science and Technology (FT-2014-01)
- Shanxi Scholarship Council of China (2015-064)
- Key Research and Development Program of Shanxi Province (201603D312005)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- constipation, gut microbiota, acetylcholinesterase, nitric oxide, gut microbiota composition, Akkermansia, Lactobacillus, Butyricimonas, Candidatus Arthromitus, Prevotella, Clostridium, Dorea, polysaccharide monosaccharide composition, bowel habits
- MeSH terms
- Animals, Chorionic Villi, Constipation, Defecation, Diphenoxylate, Gene Expression Regulation, Intestines, Male, Mice, Inbred ICR, Polysaccharides, Bacterial, Water, Neurotransmitter Agents, Mice, Spirulina
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