Modified poly(3-hydroxybutyrate)-based scaffolds in tissue engineering applications: A review
Abstract
As a member of the polyhydroxyalkanoate (PHAs) family, Poly(3-hydroxybutyrate) (PHB) has attracted much attention for a variety of medical applications because of its desirable properties such as high biocompatibility, nontoxic degradation products and high mechanical strength in comparison to other polymers in different fields including tissue engineering. There are different approaches such as making PHB alloy scaffolds, using PHB as a coating for ceramic-based scaffolds and producing composite scaffolds by using a mixture of PHB with ceramic particles utilized to improve hydrophobicity, degradation rate and brittleness. In this review, different applications of PHB, its alloys and composites in tissue engineering are explained based on the common methods of fabrication such as polymeric sponge replication, electrospinning and salt leaching.
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PHB is a bioresorbable low-molecular-weight aliphatic polyester and belongs to the most widely used biocompatible PHAs with an isotactic semicrystalline structure.
“As a bioresorbable low-molecular-weight aliphatic polyester, PHB belongs to the most widely used biocompatible PHAs with an isotactic semicrystalline structure [93].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [93]
Cites
Incidence of Anterior Cruciate Ligament Tears and Reconstruction: A 21-Year Population-Based Study
Sanders, T. L., Maradit Kremers, H., Bryan, A. J., Larson, D. R., Dahm, D. L., Levy, B. A., Stuart, M. J., & Krych, A. J. (2016) · The American Journal of Sports Medicine · doi:10.1177/0363546516629944 · Cited by 1,325 · see citing works
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Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review
Vach Agocsova, S., Culenova, M., Birova, I., Omanikova, L., Moncmanova, B., Danisovic, L., Ziaran, S., Bakos, D., & Alexy, P. (2023) · Materials · doi:10.3390/ma16124267 · Cited by 98 · see citing works
- Authors
- Soleymani Eil Bakhtiari, S., Karbasi, S., & Toloue, E. B.
- Affiliations
- Isfahan University of Medical Sciences (IR)
- Corresponding author
- Karbasi, Saeed
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 166
- Pages
- 986-998
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W3095256335
- Cited by
- 100
- References
- 1
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 18 · 2023: 30 · 2022: 20 · 2021: 13
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Keywords
- polyhydroxybutyrate, polyhydroxyalkanoates, tissue engineering scaffolds, biodegradable polymers, scaffold fabrication, electrospinning, salt leaching, biocompatibility
- MeSH terms
- Prohibitins, Polyhydroxybutyrates, Animals, Ceramics, Humans, Hydroxybutyrates, Neurons, Osteoblasts, Polyesters, Skin, Tissue Engineering, Nanocomposites, Tissue Scaffolds
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