NLRP3 inflammasome activation in human peripheral blood mononuclear cells induced by venoms secreted PLA2s

Bothropic venoms contains high amount of secreted phospholipases A2 (sPLA2s) that play a significant role in leukocyte activation and inflammation. Monocytes and lymphocytes are highly functional immune system cells that mediate and provide efficient responses during the inflammation. NLRP3 infla…