Monocyte-to-high density lipoprotein ratio (MHR) can predict the significance of angiographically intermediate coronary lesions

Abstract

Purpose: Monocyte-high density lipoprotein ratio (MHR) has recently emerged as a marker of inflammation and oxidative stress in the cardiovascular disease. We aimed to investigate whether baseline MHR is associated with functional significance of intermediate coronary artery lesions.\nMethods: Three hundred and one consecutive patients, 215 males and 86 females, who underwent fractional flow reserve (FFR) measurement for angiographically intermediate coronary stenosis (40–70% in quantitative coronary analysis) in the left anterior descending coronary artery were enrolled into the study. An FFR value of ≤0.80 was accepted for hemodynamic significance.\nResults: Of the 301 patients, 115 (38.2%) exhibited significant functional stenosis (FFR ≤ 0.80) in the FFR measurement. Patients with hemodynamically significant lesions had higher MHR values (11.6 ± 3.3 vs. 12.6 ± 2.5 p = 0.003).In stepwise multivariate logistic regression analysis, total cholesterol (OR = 1.008, 95% CI = 1.002–1.013, p < 0.010), plateletcrit (OR = 1.310, 95% CI = 1.097–1.564, p = 0.013) and MHR (OR = 2.993, 95% CI = 1.365–6.561, p = 0.008) were independent predictors of significant functional stenosis. An MHR value of 12.1 had 65% sensitivity and 55% specificity for prediction of hemodynamically significant coronary artery stenosis.\nConclusions: Increased MHR values were associated with functional significance of angiographically intermediate coronary artery stenosis.