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Cited by 377

The DOI matches its Crossref record; 210 of the 210 references it cites were found in a registry or an index.

Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation

Open access
Watts, Gerald F., Gidding, Samuel, Wierzbicki, Anthony S., Toth, Peter P., Alonso, Rodrigo, Brown, W. Virgil, Bruckert, Eric, Defesche, Joep, Lin, Khoo Kah, Livingston, Michael, Mata, Pedro, Parhofer, Klaus G., Raal, Frederick J., Santos, Raul D., Sijbrands, Eric J.G., Simpson, William G., Sullivan, David R., Susekov, Andrey V., Tomlinson, Brian, Wiegman, Albert, Yamashita, Shizuya, Kastelein, John J.P.·2014·International Journal of Cardiology

Abstract

Familial hypercholesterolaemia (FH) is a dominantly inherited disorder present from birth that markedly elevates plasma low-density lipoprotein (LDL) cholesterol and causes premature coronary heart disease. There are at least 20 million people with FH worldwide, but the majority remain undetected and current treatment is often suboptimal. To address this major gap in coronary prevention we present, from an international perspective, consensus-based guidance on the care of FH. The guidance was generated from seminars and workshops held at an international symposium. The recommendations focus on the detection, diagnosis, assessment and management of FH in adults and children, and set guidelines for clinical purposes. They also refer to best practice for cascade screening and risk notifying and testing families for FH, including use of genetic testing. Guidance on treatment is based on risk stratification, management of non-cholesterol risk factors, and safe and effective use of LDL lowering therapies. Recommendations are given on lipoprotein apheresis. The use of emerging therapies for FH is also foreshadowed. This international guidance acknowledges evidence gaps, but aims to make the best use of contemporary practice and technology to achieve the best outcomes for the care of FH. It should accordingly be employed to inform clinical judgement and be adjusted for country-specific and local health care needs and resources.

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Crossref · 10.1016/j.ijcard.2013.11.025

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Metadata

Authors
Watts, G. F., Gidding, S., Wierzbicki, A. S., Toth, P. P., Alonso, R., Brown, W. V., Bruckert, E., Defesche, J., Lin, K. K., Livingston, M., Mata, P., Parhofer, K. G., Raal, F. J., Santos, R. D., Sijbrands, E. J. G., Simpson, W. G., Sullivan, D. R., Susekov, A. V., Tomlinson, B., Wiegman, A., Yamashita, S., & Kastelein, J. J. P.
Venue
International Journal of Cardiology
Publisher
Elsevier BV
Published
2014-02
Volume
171
Issue
3
Pages
309-325
ISSN
0167-5273 (ISSN-L)
OpenAlex
W2016805353
Cited by
377
References
210
FWCI
40.12
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation. https://app.cochat.ai/papers/10.1016/j.ijcard.2013.11.025
The paper
Watts, G. F., Gidding, S., Wierzbicki, A. S., Toth, P. P., Alonso, R., Brown, W. V., Bruckert, E., Defesche, J., Lin, K. K., Livingston, M., Mata, P., Parhofer, K. G., Raal, F. J., Santos, R. D., Sijbrands, E. J. G., Simpson, W. G., Sullivan, D. R., Susekov, A. V., Tomlinson, B., . . . Kastelein, J. J. P. (2014). Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation. International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2013.11.025

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.