Cited by 188Cardiac Valve Diseases and TreatmentsAortic Disease and Treatment ApproachesCardiac Imaging and Diagnostics

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The prevalence of aortic stenosis in the elderly in Iceland and predictions for the coming decades: The AGES–Reykjavík study

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Danielsen, Ragnar, Aspelund, Thor, Harris, Tamara B., Gudnason, Vilmundur·2014·International Journal of Cardiology

DOI 10.1016/j.ijcard.2014.08.053PMC PMC4742571

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Abstract

Aims To evaluate the prevalence of significant aortic valve stenosis (AS) in a randomly selected study population of elderly individuals representing the general population of Iceland. Furthermore, to predict the number of individuals likely to have severe AS in the future.Methods and results Echocardiography and computed tomography (CT) data from individuals who participated in the AGES-Reykjavik study were used. Echocardiography data from 685 individuals (58% females) aged 67-95 years were available. In both sexes combined, the prevalence for severe AS, defined as an aortic valve area index of <0.6 cm2/m2, in the age groups<70, 70-79 and ≥80 years was 0.92%, 2.4% and 7.3%, respectively. A ROC analysis on the relation between the echocardiography data and the aortic valve calcium score on CT defined a score≥500 to be indicative of severe AS. Subsequently, in a CT study cohort of 5256 individuals the prevalence of severe AS in the same age groups was 0.80%, 4.0% and 9.5%, respectively. Overall, the prevalence of severe AS by echocardiography and CT in individuals≥70 years was 4.3% and 5.9%, respectively. A prediction on the number of elderly≥70 years for the coming decades demonstrated that patients with severe AS will have increased 2.4 fold by the year 2040 and will more than triple by the year 2060.Conclusion This study, in a cohort of elderly individuals representative of the general population in a Nordic country, predicts that AS will be a large health problem in the coming decades.

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“Several epidemiological studies and surveys clearly indicate that many elderly patients with symptomatic significant AS are not even evaluated for AVI by their attending general practitioner or cardiologist [1, 5, 8].”
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Method
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“Several epidemiological studies and surveys clearly indicate that many elderly patients with symptomatic significant AS are not even evaluated for AVI by their attending general practitioner or cardiologist [1, 5, 8].”
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Additional file 19 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606473
Additional file 23 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J. T., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606497
Additional file 9 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606443
Additional file 8 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606440
Additional file 6 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606431
Additional file 13 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J. T., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606455
Additional file 22 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606494
Additional file 14 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J. T., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606458
Additional file 18 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606470
Additional file 5 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606428
Additional file 4 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606425
Additional file 24 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606500
Additional file 1 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606416
Additional file 21 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606485
Additional file 17 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606467
Additional file 10 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606446
Additional file 20 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606479
Additional file 16 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J. T., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606464
Additional file 26 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606506
Additional file 2 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606419
Additional file 7 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606434
Additional file 3 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606422
Additional file 11 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606449
Additional file 25 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606503
Additional file 12 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J. T., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606452
Additional file 1 of Doppler flow morphology characteristics of epiaortic arteries in aortic valve pathologies: a retrospective study on a cohort of patients with ischemic stroke
Meyer, S., Wilde, L., Wolf, F., Liman, J., Bähr, M., & Maier, I. (2024) · Figshare · doi:10.6084/m9.figshare.26595017
Additional file 15 of CircRNA/lncRNA–miRNA–mRNA network and gene landscape in calcific aortic valve disease
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J. T., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606461
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Authors: Danielsen, R., Aspelund, T., Harris, T. B., & Gudnason, V.
Affiliations: University of Iceland (IS)
National Institutes of Health (US)
ORCID: Aspelund, Thor
Harris, Tamara B.
Gudnason, Vilmundur
Venue: International Journal of Cardiology
Publisher: Elsevier BV
Published: 2014-10
Volume: 176
Issue: 3
Pages: 916-922
ISSN: 0167-5273 (ISSN-L)
DOI: 10.1016/j.ijcard.2014.08.053
PMC: PMC4742571
OpenAlex: W1992419135
Cited by: 168
References: 35
Citations by year: 2026: 21 · 2025: 19 · 2024: 26 · 2023: 24 · 2022: 21 · 2021: 14 · 2020: 8 · 2019: 9 · 2018: 9 · 2017: 9 · 2016: 5 · 2015: 3
FWCI: 3.89
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: International Journal of Cardiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Hirsla (Landspítali University Hospital) (submittedVersion)
Funders: National Institutes of Health
National Institute on Aging (N01-AG12100, ZIAAG007380)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Aortic Disease and Treatment Approaches
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Keywords: aortic stenosis, prevalence, older adults, AGES-Reykjavik Study, aortic valve calcium score, echocardiography, computed tomography, disease burden projections, Iceland
MeSH terms: Aged, Aged, 80 and over, Aging, Aortic Valve Stenosis, Female, Humans, Iceland, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Cohort Studies, Prevalence

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The prevalence of aortic stenosis in the elderly in Iceland and predictions for the coming decades: The AGES–Reykjavík study

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