Association of sST2 and hs-CRP levels with new-onset atrial fibrillation in coronary artery disease
Abstract
Background The data on biomarkers as predictors of atrial fibrillation (AF) in patients with coronary artery disease (CAD) are limited. Methods A total of 1946 patients with CAD were recruited to the ARTEMIS study. At baseline, the study patients underwent clinical and echocardiographic examinations and had laboratory tests. The patients (n=1710) with the information about the occurrence of new-onset AF during the follow-up were included in the present analysis. Results During 5.7±1.5years of follow-up, 143 (8.4%) patients developed a new-onset AF. Higher values of soluble ST2 (sST2) (20.2±10.8 vs. 17.5±7.2ng/mL, p=0.005), high-sensitivity troponin T (hs-TnT) (11.9±10.2 vs. 10.3±8.3ng/L, p=0.005), high-sensitivity C-reactive protein (hs-CRP) (3.3±5.9 vs. 2.0±4.4mg/L, p Conclusion A biomarker of fibrosis, sST2, and a biomarker of inflammation, hs-CRP, predict the risk of occurrence of new-onset AF in patients with CAD. These biomarkers contributed to the discrimination of the AF risk model, but did not improve it markedly.
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Elite athletes may present higher levels of profibrotic markers which have been associated with incident or recurrent AF in the general population, including galectin-3, ST2, miR-21, TIMP-1, CITP, and PICP.
“Elite athletes may present higher levels of profibrotic markers which have been associated with incident or recurrent AF in the general population [66,67,68], including galectin-3 [69], the suppression of tumorigenicity 2 (ST2) [70], and microRNA-21 (miR-21) [71], as well as tissue inhibitors of metalloproteinase 1 (TIMP-1), C-terminal telopeptide of type I collagen (CITP), and procollagen type I”
From Atrial Fibrillation in Elite Athletes: A Comprehensive Review of the Literature (2024) · cites this paper as [66]
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References 43 · Cited by 65
- Authors
- Nortamo, S., Ukkola, O., Lepojärvi, S., Kenttä, T., Kiviniemi, A., Junttila, J., Huikuri, H., & Perkiömäki, J.
- Affiliations
- Oulu University Hospital (FI)
- Corresponding author
- Perkiömäki, Juha
- Venue
- International Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 248
- Pages
- 173-178
- ISSN
- 0167-5273 (ISSN-L)
- OpenAlex
- W2757442080
- Cited by
- 65
- References
- 43
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 10 · 2023: 5 · 2022: 6 · 2021: 10 · 2020: 13 · 2019: 5 · 2018: 5 · 2017: 1 · 2016: 1
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sigrid Juselius Foundation
- Finnish Foundation for Cardiovascular Research
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- coronary artery disease, soluble ST2, high-sensitivity C-reactive protein, high-sensitivity troponin T, brain natriuretic peptide, biomarkers, fibrosis, inflammation, risk prediction, left atrial diameter, cholesterol-lowering drugs, echocardiography, risk factors
- MeSH terms
- Interleukin-1 Receptor-Like 1 Protein, Aged, Atrial Fibrillation, C-Reactive Protein, Coronary Artery Disease, Female, Follow-Up Studies, Humans, Male, Middle Aged, Biomarkers
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