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Ten-year experience with fungal peritonitis in peritoneal dialysis patients: antifungal susceptibility patterns in a North-American center

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Levallois, Jasmin, Nadeau-Fredette, Annie-Claire, Labbé, Annie-Claude, Laverdière, Michel, Ouimet, Denis, Vallée, Michel·2012·International Journal of Infectious Diseases

Abstract

OBJECTIVE: To describe the clinical and microbiological features associated with fungal peritonitis in peritoneal dialysis (PD) patients at Hôpital Maisonneuve-Rosemont, from August 1996 to July 2006. METHODS: Cases were retrieved from the microbiology laboratory culture registry. Antifungal susceptibility was determined by the Clinical and Laboratory Standards Institute M27A3 method. RESULTS: Among 288 PD patients (total follow-up of 7258 patient-months), nine were found with fungal peritonitis. Candida spp were identified in all of them, with a majority of non-albicans Candida species. Resistance to fluconazole, itraconazole, or voriconazole was as frequent as potential resistance to amphotericin B. No isolate was resistant to caspofungin and one was resistant to micafungin. Prior bacterial peritonitis was frequent (67%). All patients had their PD catheter removed and all of them survived. CONCLUSIONS: In our institution, fungal peritonitis in PD patients is rare. All cases were caused by Candida species. Variable susceptibility patterns were observed, which may influence the initial empirical antifungal therapy and underscore the importance of individual speciation and susceptibility testing of invasive Candida isolates.

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Metadata

Authors
Levallois, J., Nadeau-Fredette, A.-C., Labbé, A.-C., Laverdière, M., Ouimet, D., & Vallée, M.
Affiliations
Hôpital Maisonneuve-Rosemont (CA)
Corresponding author
Vallée, Michel
Venue
International Journal of Infectious Diseases
Publisher
Elsevier BV
Published
2012-01
Volume
16
Issue
1
Pages
e41-e43
ISSN
1201-9712 (ISSN-L)
OpenAlex
W2002605200
Cited by
47
References
16
Citations by year
2026: 4 · 2025: 2 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 1 · 2013: 3
FWCI
0.87
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
  • Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Keywords
fungal peritonitis, peritoneal dialysis, Candida, non-albicans Candida, antifungal susceptibility, fluconazole resistance, itraconazole resistance, voriconazole resistance, amphotericin B resistance, caspofungin, micafungin, peritoneal catheter removal, invasive candidiasis
MeSH terms
Caspofungin, Micafungin, Adult, Aged, Amphotericin B, Antifungal Agents, Candida, Female, Follow-Up Studies, Humans, Male, Microbial Sensitivity Tests, Middle Aged, Mycoses, North America, Peritoneal Dialysis, Peritonitis, Pyrimidines, Triazoles, Fluconazole, Itraconazole, Drug Resistance, Fungal, Echinocandins, Lipopeptides, Voriconazole

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Levallois, J., Nadeau-Fredette, A.-C., Labbé, A.-C., Laverdière, M., Ouimet, D., & Vallée, M. (2012). Ten-year experience with fungal peritonitis in peritoneal dialysis patients: antifungal susceptibility patterns in a North-American center. International Journal of Infectious Diseases. https://doi.org/10.1016/j.ijid.2011.09.016

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.