Enhancement of dissolution rate of poorly soluble active ingredients by supercritical fluid processes
Abstract
In this second of two articles, we show that several supercritical processes have been developed to prepare composite particles of poorly soluble active ingredients. Microencapsulation, cyclodextrin inclusion and impregnation allow to incorporate poorly soluble materials in fast-dissolving hydrophilic excipients, leading to promising results in terms of dissolution rate enhancement.
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Mainly, drug loaded PEG and poloxamers micro-particles are described for PGSS.
“Mainly, drug loaded PEG and poloxamers micro-particles are described [92].”
From Recent advances in the synthesis of aliphatic polyesters by ring-opening polymerization☆ (2008) · cites this paper as [92]
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References 13 · Cited by 61
- Authors
- Perrut, M., Jung, J., & Leboeuf, F.
- Affiliations
- Separex (France) (FR)
- Corresponding author
- Perrut, M.
- ORCID
- Jung, J.
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 288
- Issue
- 1
- Pages
- 11-16
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W1580259492
- Cited by
- 61
- References
- 13
- Citations by year
- 2024: 1 · 2023: 4 · 2022: 2 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 4
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Physical Sciences › Engineering › Biomedical Engineering › Phase Equilibria and Thermodynamics
- Physical Sciences › Materials Science › Materials Chemistry › Crystallization and Solubility Studies
- Keywords
- poorly water-soluble drugs, dissolution enhancement, supercritical fluid processing, composite particles, microencapsulation, cyclodextrin inclusion complexes, impregnation, drug solubility
- MeSH terms
- Pharmaceutical Preparations, Solubility, Chromatography, Supercritical Fluid, Nanostructures
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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