Intratracheal and subcutaneous liposomal VIP normalizes arterial pressure in spontaneously hypertensive hamsters
Abstract
We determined whether a single intratracheal and subcutaneous administration of biocompatible and biodegradable vasoactive intestinal peptide self-associated with sterically stabilized liposomes (VIP-SSL) normalizes mean arterial pressure (MAP) in spontaneously hypertensive hamsters (SHH). We found that VIP-SSL (0.1 nmol) administered by either routes normalizes MAP (p < 0.05). Maximal effect was observed within 10-20 min and lasted for 6 h. VIP-SSL had no significant effects on heart rate. VIP alone (0.1 nmol) and empty SSL had no significant effects on MAP. VIP-SSL (0.1 nmol) had no significant effects on MAP and heart rate in age/genetically-matched control hamsters. Given these data, we suggest that pulmonary and subcutaneous delivery of VIP-SSL should be further developed as peptide nanomedicine for essential hypertension.
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Liposomal formulation of vasoactive intestinal peptide via subcutaneous and intratracheal routes is also effective in delivering antihypertensive effects.
“It is worth adding that administration of this liposomal formulation via other routes (subcutaneous and intratracheal) is also effective in delivering antihypertensive effects.146”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [146]
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References 4 · Cited by 15
- Authors
- Rubinstein, I., Ikezaki, H., & Önyüksel, H.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Rubinstein, Israel
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 316
- Issue
- 1-2
- Pages
- 144-147
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W2001612491
- Cited by
- 15
- References
- 4
- Citations by year
- 2024: 1 · 2022: 2 · 2019: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Defense
- National Institutes of Health (5r01ag024026-04)
- National Institute on Aging (R01 AG-024026)
- National Heart, Lung, and Blood Institute (R01 HL72343)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- vasoactive intestinal peptide, liposomal drug delivery, PEGylated liposomes, intratracheal administration, subcutaneous administration, arterial blood pressure, essential hypertension, pulmonary drug delivery, heart rate
- MeSH terms
- Animals, Antihypertensive Agents, Blood Pressure, Cricetinae, Hypertension, Injections, Subcutaneous, Intubation, Intratracheal, Liposomes, Male, Vasoactive Intestinal Peptide
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