The DOI matches its Crossref record; 384 of the 384 references it cites were found in a registry or an index.
Protein aggregation – Mechanisms, detection, and control
Abstract
Protein aggregation has been recognized as one of the major challenges in the development and commercialization of successful protein-based drug products because of the inherent and high aggregation tendency during various manufacturing processes, storage, and administration. Protein aggregates may impact significantly the product quality, safety and/or efficacy. This review is intended to summarize four major aspects of protein aggregation - (1) aggregation mechanisms, (2) aggregation-influencing factors, (3) detection of protein aggregates, and (4) control of protein aggregation based on recent literature in this area.
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Cites
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Protein aggregation—Pathways and influencing factors
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Self-citationProtein aggregation kinetics, mechanism, and curve-fitting: A review of the literature
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Engineering Challenges in Therapeutic Protein Product and Process Design
Papathanasiou, M. M., & Kontoravdi, C. (2020) · Current Opinion in Chemical Engineering · doi:10.1016/j.coche.2019.11.010 · Cited by 57
Meng, A., Luan, B., Zhang, W., Zheng, Y., Guo, B., & Zhang, B. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.132911 · Cited by 51
Probst, C. (2020) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2019.05.018 · Cited by 48
Deng, Y., Gao, L., Zhang, Z., Guan, Z., Zheng, N., Wei, P., Du, S., Wang, Y., Li, Z., Cai, Y., et al. (2025) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2025.111170 · Cited by 26
From cell clones to recombinant protein product heterogeneity in Chinese hamster ovary cell systems
Wang, C., Guo, X., Wang, W., Li, J.-X., & Wang, T.-Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031324 · Cited by 9
Self-citation
Metadata
- Authors
- Wang, W., & Roberts, C. J.
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 550
- Issue
- 1-2
- Pages
- 251-268
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W2888677649
- Cited by
- 299
- References
- 384
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, W., & Roberts, C. J. (2018). Protein aggregation – Mechanisms, detection, and control. International Journal of Pharmaceutics. https://doi.org/10.1016/j.ijpharm.2018.08.043
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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