The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Bile acid transporter mediated STC/Soluplus self-assembled hybrid nanoparticles for enhancing the oral drug bioavailability
Abstract
The nano-particulate system for oral delivery faces a big challenge across the gastrointestinal bio-barriers. The aim was to explore the potential applications of bile acid transporter mediated the self-assembled hybrid nanoparticles (SHNPs) of sodium taurocholate (STC) and polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (Soluplus) for augmenting the oral delivery of poorly water-soluble drugs. Felodipine (FLDP) was chosen as a model drug. The self-assembly of STC with Soluplus to load FLDP and the microstructure of the SHNPs were confirmed using molecular simulation, STC determination by high performance liquid chromatography (HPLC) and transmission electron microscope. Results showed that STC was integrated with Soluplus on the surface of nanoparticles by hydrophobic interactions. The permeability of FLDP loaded STC/Soluplus SHNPs was STC dependent in the ileum, which was inhibited by the higher concentrations of STC and the inhibitor of apical sodium-dependent bile acid transporter (ASBT). STC/Soluplus (1:9) SHNPs significantly improved the drug loading of FLDP, achieved the highest permeability of FLDP and realized 1.6-fold of the area under the curve (AUC) of Soluplus self-assembled nanoparticles (SNPs). A water-quenching fluorescent probe P4 was loaded into the STC/Soluplus SHNPs, which verified that the SHNPs were transferred intactly across the ileum. In conclusion, STC/Soluplus SHNPs via ASBT are a potential strategy for enhancing the oral bioavailability of poorly water-soluble drugs.
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“Soluplus micelles, demonstrating superior eye tolerance and corneal permeability, have been effectively used as topical ocular medication delivery systems for these poorly water-soluble drugs [108].”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [108]
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Cited by
Sorted by citations
From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics
Sun, M., Wang, J., Fan, W., Wang, K., Wang, Y., Zhang, J., Ding, S., Zhang, C., Feng, Z., Wang, Y.-G., et al. (2025) · Materials today. Bio · doi:10.1016/j.mtbio.2025.102537 · Cited by 7
“Soluplus micelles, demonstrating superior eye tolerance and corneal permeability, have been effectively used as topical ocular medication delivery systems for these poorly water-soluble drugs [108].”
Self-citation
Metadata
- Authors
- Zhang, S., Cui, D., Xu, J., Wang, J., Wei, Q., & Xiong, S.
- Affiliations
- Zhejiang University of Technology (CN)
- Corresponding author
- Xiong, Subin
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 579
- Pages
- 119120
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W3004627283
- Cited by
- 19
- References
- 28
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 3
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Zhejiang Province
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- bile acid transporters, ASBT, sodium taurocholate, Soluplus, felodipine, oral bioavailability, poorly water-soluble drugs, intestinal permeability, ileum, drug loading
- MeSH terms
- Administration, Oral, Animals, Drug Carriers, Drug Compounding, Male, Permeability, Polyethylene Glycols, Polyvinyls, Taurocholic Acid, Felodipine, Area Under Curve, Symporters, Organic Anion Transporters, Sodium-Dependent, Mice, Rats, Nanoparticles, Hydrophobic and Hydrophilic Interactions, Drug Liberation
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