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A comparative study of the in vitro permeation of 2-phenoxyethanol in the skin PAMPA model and mammalian skin
Open accessAbstract
For permeation studies that use excised skin, experimental data may show variability associated with the use of biological tissues. As a consequence, achieving reproducible results and data interpretation may be challenging. The skin parallel artificial membrane permeability assay (skin PAMPA) model has been proposed as a high-throughput tool for predicting skin permeation of chemicals. A number of skin cleansing wipe formulations for the diaper area of infants contain 2-phenoxyethanol (PE) as a preservative and cetylpyridinium chloride (CPC) as a surfactant with antimicrobial activity. However, information regarding cutaneous absorption of PE and CPC in the scientific literatures is remarkably limited. The main aim of the present study was to assess the suitability of the skin PAMPA model for prediction of skin permeation of PE. A secondary aim was to investigate the influence of CPC on the dermal absorption of PE. PE (1 % w/w) was prepared in two vehicles, namely propylene glycol (PG) and water-PG (WP). Permeability of PE was investigated in vitro using the skin PAMPA membrane, porcine skin and human skin under finite dose conditions. The highest permeation of PE was observed for the water-PG preparation with 0.2 % w/w of CPC. This finding was consistently observed in the skin PAMPA model and in Franz cell studies using porcine skin and human skin. Permeation of CPC was not detected in the three permeation models. However, permeation of PE increased significantly (p < 0.05) in the presence of CPC compared with formulations without CPC. When comparing the skin PAMPA data and the mammalian skin data for the cumulative amount of PE permeated, the r 2 values for PAMPA-porcine skin and PAMPA-human skin were 0.84 and 0.89, respectively. The findings in this study demonstrate the capability of the skin PAMPA model to differentiate between various doses and formulations and are encouraging for further applications of this model as a high throughput screening tool in topical formulation development.
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“notably, the authors observed a positive correlation for the total amount of permeated phenoxyethanol between this artificial membrane and porcine or human skin placed in a Franz diffusion cell, a widely used system to test drug permeation in vitro [16,17,18].”
From Recreating Human Skin In Vitro: Should the Microbiota Be Taken into Account? (2024) · cites this paper as [16]
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Pig and guinea pig skin as surrogates for human in vitro penetration studies: A quantitative review
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Alternatives to Biological Skin in Permeation Studies: Current Trends and Possibilities
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Skin–PAMPA: A new method for fast prediction of skin penetration
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Transdermal Drug Delivery Systems: Methods for Enhancing Skin Permeability and Their Evaluation
Бахрушина, Е. О., Shumkova, M. M., Avdonina, Y. V., Ananian, A. A., Babazadeh, M., Pouya, G., Grikh, V. V., Zubareva, I. M., Kosenkova, S. I., Krasnyuk, I. I., et al. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17070936 · Cited by 65
Gómez-Urios, C., Puchades-Colera, P., Frígola, A., Esteve, M. J., Blesa, J., & López-Malo, D. (2024) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2024.125864 · Cited by 24
Recreating Human Skin In Vitro: Should the Microbiota Be Taken into Account?
Galvan, A., Pellicciari, C., & Calderan, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021165 · Cited by 11
Duan, Q., Ye, Z., Zhou, K., Wang, F., Lian, C., Shang, Y., & Liu, H. (2024) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.4c00735 · Cited by 7
In vivo permeation of 2-phenoxyethanol in human skin
Rahma, A., Gu, J., & Lane, M. E. (2024) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2024.106889 · Cited by 4
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Metadata
- Authors
- Rahma, A., Lane, M. E., & Sinkó, B.
- Affiliations
- Bandung Institute of Technology (ID)
- UCL School of Pharmacy (GB)
- Corresponding author
- Rahma, Annisa
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2023-03
- Volume
- 635
- Pages
- 122692
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W4319441666
- Cited by
- 12
- References
- 46
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- green
- discovery.ucl.ac.uk
- Licence
- Locations
- International Journal of Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Kementerian Keuangan Republik Indonesia (S-1778/LPDP.4/2019)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal skin health care
- Keywords
- 2-phenoxyethanol, skin permeation, cetylpyridinium chloride, percutaneous absorption, preservatives, surfactants, propylene glycol vehicle, porcine skin, human skin, Franz diffusion cell, high-throughput screening
- MeSH terms
- Administration, Cutaneous, Animals, Ethylene Glycols, Humans, Mammals, Membranes, Artificial, Permeability, Skin, Skin Absorption, Swine, Water, Propylene Glycol
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