CoChat
Sign Up
Cited by 9

The DOI matches its Crossref record.

Chitosan nanomedicines-engineered bifidobacteria complexes for effective colorectal tumor-targeted delivery of SN-38

Wu, Danjun, Fu, Kaili, Zhang, Wangyang, Li, Yazhen, Ji, Yaning, Dai, Yiwei, Yang, Gensheng·2024·International Journal of Pharmaceutics
DOI 10.1016/j.ijpharm.2024.124283
Open this paper in CoChat — free account

Abstract

The clinical application of 7-ethyl hydroxy-camptothecin (SN-38) maintains challenges not only due to its poor solubility and stability but also the lack of effective carriers to actively deliver SN-38 to deep tumor sites. Although SN-38-based nanomedicines could improve the solubility and stability from different aspects, the tumor targeting efficiency remains very low. Leveraging the hypoxic taxis of bifidobacteria bifidum (B. bifi) to the deep tumor area, we report SN-38-based nanomedicines-engineered bifidobacterial complexes for effective tumor-targeted delivery. Firstly, SN-38 was covalently coupled with poly-L-glutamic acid (L-PGA) and obtained soluble polymeric prodrug L-PGA-SN38 to improve its solubility and stability. To prolong the drug release, L-PGA-SN38 was mildly complexed with chitosan to form nanomedicines, and nanomedicines engineered B. bifi were further elaborated via electrostatic interaction of the excess of cationic chitosan shell from nanomedicines and anionic teichoic acid from B. bifi. The engineered B. bifi complexes inherited the bioactivity of native B. bifi and exhibited distinctly enhanced accumulation at the tumor site. More importantly, significantly elevated anti-tumor efficacy was achieved after the treatment of CS-L-PGA-SN38 NPs/B. bifi complexes, with favorable tumor suppression up to 80%. Such a B. bifi-mediated delivery system offers a promising platform for effective drug delivery and enhanced drug accumulation in the hypoxia deep tumor…

Overview

Integrity signals

Registry

Crossref · 10.1016/j.ijpharm.2024.124283

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 36

  1. Abdolalipour, 2020, Evaluation of the antitumor immune responses of probiotic bifidobacterium bifidum in human papillomavirus-induced tumor model, Microb. Pathog., 145, 10.1016/j.micpath.2020.104207 · DOI
  2. Badgeley, 2021, Effect of probiotics and gut microbiota on anti-cancer drugs: mechanistic perspectives, Biochim. Biophys. Acta Rev. Cancer, 1875, 10.1016/j.bbcan.2020.188494 · DOI
  3. Brown, 2013, Wall teichoic acids of gram-positive bacteria, Annu. Rev. Microbiol., 67, 313, 10.1146/annurev-micro-092412-155620 · DOI · Paper page
  4. Chen, 2019, Synthesis of a SN38 prodrug grafted to amphiphilic phosphorylcholine polymers and their prodrug miceller properties, New J. Chem., 43, 481, 10.1039/C8NJ04908D · DOI
  5. Chen, 2020, Self-mineralized photothermal bacteria hybridizing with mitochondria-targeted metal-organic frameworks for augmenting photothermal tumor therapy, Adv. Funct. Mater., 30, 1909806, 10.1002/adfm.201909806 · DOI
  6. Chen, 2022, Advances in salmonella typhimurium-based drug delivery system for cancer therapy, Adv. Drug Deliver. Rev., 185, 10.1016/j.addr.2022.114295 · DOI
  7. Ding, 2021, Novel engineered bacterium/black phosphorus quantum dot hybrid system for hypoxic tumor targeting and efficient photodynamic therapy, ACS Appl. Mater. Interfaces, 13, 10564, 10.1021/acsami.0c20254 · DOI
  8. Divya, 2017, Antimicrobial properties of chitosan nanoparticles: mode of action and factors affecting activity, Fiber. Polym., 18, 221, 10.1007/s12221-017-6690-1 · DOI
  9. Dong, 2019, Application and design of esterase-responsive nanoparticles for cancer therapy, Drug Deliv., 26, 416, 10.1080/10717544.2019.1588424 · DOI
  10. Faghfoori, 2021, Anticancer effects of bifidobacteria on colon cancer cell lines, Cancer Cell Int., 21, 258, 10.1186/s12935-021-01971-3 · DOI
  11. Fan, 2019, Engineered bacterial bioreactor for tumor therapy via fenton-like reaction with localized H2O2 generation, Adv. Mater., 31, 1808278, 10.1002/adma.201808278 · DOI
  12. Fan, 2023, Role of micelle size in cell transcytosis-based tumor extravasation, infiltration, and treatment efficacy, Nano Lett., 23, 3904, 10.1021/acs.nanolett.3c00449 · DOI
  13. Gibson, 1999, Colonic epithelial cell activation and the paradoxical effects of butyrate, Carcinogenesis, 20, 539, 10.1093/carcin/20.4.539 · DOI
  14. Jafari, 2023, Targeted bacteria-mediated therapy of mouse colorectal cancer using baicalin, a natural glucuronide compound, and E. Coli overexpressing β–glucuronidase, Int. J. Pharm., 642, 10.1016/j.ijpharm.2023.123099 · DOI
  15. Kasinskas, 2006, Specifically chemotax and proliferate in heterogeneous tumor tissue in vitro, Biotechnol. Bioeng., 94, 710, 10.1002/bit.20883 · DOI
  16. Kimura, 1980, Selective localization and growth of bifidobacterium bifidum in mouse tumors following intravenous administration, Cancer Res., 40, 2061
  17. Kramer, 2018, Bacterial therapy of cancer: Promises, limitations, and insights for future directions, Front. Microbiol., 9, 3518060, 10.3389/fmicb.2018.00016 · DOI · Paper page
  18. Lee, 2022, Pheophorbide A and SN38 conjugated hyaluronan nanoparticles for photodynamic- and cascadic chemotherapy of cancer stem-like ovarian cancer, Carbohydr. Polym., 289, 10.1016/j.carbpol.2022.119455 · DOI
  19. Lee, 2002, Chitosan oligosaccharides, dp 2–8, have prebiotic effect on the bifidobacterium bifidium and lactobacillus sp, Anaerobe, 8, 319, 10.1016/S1075-9964(03)00030-1 · DOI
  20. Lei, 2021, Nanoscale platform for delivery of active irinox to combat pancreatic cancer, J. Control. Release, 330, 1229, 10.1016/j.jconrel.2020.11.029 · DOI
  21. Li, 2022, Targeted delivery of DNA topoisomerase inhibitor SN38 to intracranial tumors of glioblastoma using sub-5 ultrafine iron oxide nanoparticles, Adv. Healthc. Mater., 11, 2102816, 10.1002/adhm.202102816 · DOI
  22. Liu, 2015, Comparison of two self-assembled macromolecular prodrug micelles with different conjugate positions of SN38 for enhancing antitumor activity, Int. J. Nanomedicine, 10, 2295
  23. Medina, 1998, Sodium butyrate inhibits carcinoma development in a 1, 2-dimethylhydrazine-induced rat colon cancer, J. Parenter. Enteral Nutr., 22, 14, 10.1177/014860719802200114 · DOI
  24. Nowak, 2019, Anti-proliferative, pro-apoptotic and anti-oxidative activity of lactobacillus and bifidobacterium strains: a review of mechanisms and therapeutic perspectives, Crit. Rev. Food Sci. Nutr., 59, 3456, 10.1080/10408398.2018.1494539 · DOI
  25. Palakurthi, 2015, Challenges in SN38 drug delivery: current success and future directions, Expert Opin. Drug Deliv., 12, 1911, 10.1517/17425247.2015.1070142 · DOI
  26. Sarkar, 2016, Bifidobacteria—insight into clinical outcomes and mechanisms of its probiotic action, Microbiol. Res., 192, 159, 10.1016/j.micres.2016.07.001 · DOI
  27. Staedtke, 2016, Clostridium novyi-NT in cancer therapy, Genes. Dis., 3, 144, 10.1016/j.gendis.2016.01.003 · DOI
  28. Sung, 2021, Global cancer statistics 2020: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA-Cancer J. Clin., 71, 209, 10.3322/caac.21660 · DOI · Paper page
  29. Taniguchi, 2010, Targeting solid tumors with non-pathogenic obligate anaerobic bacteria, Cancer Sci., 101, 1925, 10.1111/j.1349-7006.2010.01628.x · DOI
  30. Veltman, 2022, Characterization of the selective binding of modified chitosan nanoparticles to gram-negative bacteria strains, Int. J. Biol. Macromol., 194, 666, 10.1016/j.ijbiomac.2021.11.111 · DOI
  31. Wu, 2021, A biocompatible superparamagnetic chitosan-based nanoplatform enabling targeted SN-38 delivery for colorectal cancer therapy, Carbohydr. Polym., 274, 10.1016/j.carbpol.2021.118641 · DOI
  32. Wu, 2021, Targeting hypoxia for sensitization of tumors to apoptosis enhancement through supramolecular biohybrid bacteria, Int. J. Pharm., 605, 10.1016/j.ijpharm.2021.120817 · DOI
  33. Wu, 2019, Novel SN38 derivative-based liposome as anticancer prodrug: an in vitro and in vivo study, Int. J. Nanomedicine., 14, 75, 10.2147/IJN.S187906 · DOI
  34. Wu, 2023, Gold nanorods-loaded chitosan-based nanomedicine platform enabling an effective tumor regression in vivo, Int. J. Pharm., 632, 10.1016/j.ijpharm.2022.122561 · DOI
  35. Wu, 2023, Escherichia coli nissle 1917-driven microrobots for effective tumor targeted drug delivery and tumor regression, Acta Biomater., 169, 477, 10.1016/j.actbio.2023.07.051 · DOI
  36. Xing, 2019, Novel lipophilic SN38 prodrug forming stable liposomes for colorectal carcinoma therapy, Int. J. Nanomed., 14, 5201, 10.2147/IJN.S204965 · DOI

Cited by

Sorted by citations

Metadata

Authors
Wu, D., Fu, K., Zhang, W., Li, Y., Ji, Y., Dai, Y., & Yang, G.
ORCID
Yang, Gensheng
Venue
International Journal of Pharmaceutics
Publisher
Elsevier BV
Published
2024-06
Volume
659
Pages
124283
ISSN
0378-5173
DOI
10.1016/j.ijpharm.2024.124283
Cited by
9
References
0
Language
en
Licence
Funders
  • Zhejiang Province Natural Science Foundation (LY20H300006)
  • National Natural Science Foundation of China (51803181, 22078297)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review