Transdiagnostic dimensions of anxiety: Neural mechanisms, executive functions, and new directions
Abstract
Converging neuroscientific and psychological evidence points to several transdiagnostic factors that cut across DSM-defined disorders, which both affect and are affected by executive dysfunction. Two of these factors, anxious apprehension and anxious arousal, have helped bridge the gap between psychological and neurobiological models of anxiety. The present integration of diverse findings advances an understanding of the relationships between these transdiagnostic anxiety dimensions, their interactions with each other and executive function, and their neural mechanisms. Additionally, a discussion is provided concerning how these constructs fit within the Research Domain Criteria (RDoC) matrix developed by the National Institutes of Mental Health and how they relate to other anxiety constructs studied with different methods and at other units of analysis. Suggestions for future research are offered, including how to (1) improve measurement and delineation of these constructs, (2) use new neuroimaging methods and theoretical approaches of how the brain functions to build neural mechanistic models of these constructs, and (3) advance understanding of the relationships of these constructs to diverse emotional phenomena and executive functions.
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Patients with anxiety disorders cannot timely stop their cycle of comparing advantages and costs of options and move to action after a decision has already been made.
“пациенты с тревожными расстройствами не могут своевременно остановить свой цикл сопоставления преимуществ и издержек рассматриваемых опций и перейти к действию после того, как решение уже принято (Sharp et al., 2015).”
From Когнитивные механизмы дисфункционального принятия решений при психических расстройствах (2025) · cites this paper as Sharp et al., 2015
Weakened cognitive functions can be a risk factor and a component supporting anxiety disorders.
“Furthermore, weakened cognitive functions can be arisk factor, as well as acomponent supporting anxiety disorders (Sharp et al . 2015).”
From Effectiveness of a training programme based on acceptance and commitment therapy aimed at older adults – no moderating role of cognitive functioning (2021) · cites this paper as Sharp et al . 2015
The DSM excludes severe forms of psychopathology when benchmarks for number and duration of symptoms are not met.
“Additionally, the DSM excludes severe forms of psychopathology, when the benchmarks for number and duration of symptoms are not met [5].”
From The effectiveness of acceptance and commitment therapy-based intervention in therapy for mental health disorders - case study (2020) · cites this paper as [5]
The DSM nosology has received criticism due to evident shortcomings.
“In recent decades, thenosology applied in sub sequent editions oftheDSM has received some criticism due to its evident shortcomings [5].”
From The effectiveness of acceptance and commitment therapy-based intervention in therapy for mental health disorders - case study (2020) · cites this paper as [5]
Programmes based on ACT are in line with the transdiagnostic approach, which emphasises that components of psychopathology are present across DSM-categorised disorders.
“Programmes based on ACT are in line with thetransdiagnostic approach [5], which empha sises that components of psychopathology are present across DSM-categorised disorders [34].”
From The effectiveness of acceptance and commitment therapy-based intervention in therapy for mental health disorders - case study (2020) · cites this paper as [5]
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References 125 · Cited by 140
- Authors
- Sharp, P. B., Miller, G. A., & Heller, W.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- Corresponding author
- Sharp, Paul B.
- Venue
- International Journal of Psychophysiology
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 98
- Issue
- 2
- Pages
- 365-377
- ISSN
- 0167-8760 (ISSN-L)
- OpenAlex
- W761003534
- Cited by
- 140
- References
- 125
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 10 · 2023: 11 · 2022: 20 · 2021: 13 · 2020: 16 · 2019: 14 · 2018: 6 · 2017: 9 · 2016: 9 · 2015: 2
- FWCI
- 13.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Psychophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- anxious apprehension, anxious arousal, executive dysfunction, Research Domain Criteria, anxiety dimensions
- MeSH terms
- Anxiety, Anxiety Disorders, Brain, Humans, Executive Function
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