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Radiotherapy Dose–Volume Effects on Salivary Gland Function
Open accessAbstract
Publications relating parotid dose-volume characteristics to radiotherapy-induced salivary toxicity were reviewed. Late salivary dysfunction has been correlated to the mean parotid gland dose, with recovery occurring with time. Severe xerostomia (defined as long-term salivary function of <25% of baseline) is usually avoided if at least one parotid gland is spared to a mean dose of less than ≈20 Gy or if both glands are spared to less than ≈25 Gy (mean dose). For complex, partial-volume RT patterns (e.g., intensity-modulated radiotherapy), each parotid mean dose should be kept as low as possible, consistent with the desired clinical target volume coverage. A lower parotid mean dose usually results in better function. Submandibular gland sparing also significantly decreases the risk of xerostomia. The currently available predictive models are imprecise, and additional study is required to identify more accurate models of xerostomia risk.
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Cited by
Stewart, F. A., Akleyev, A. V., Hauer-Jensen, M., Hendry, J. H., Kleiman, N. J., MacVittie, T. J., Aleman, B. M., Edgar, A. B., Mabuchi, K., Muirhead, C. R., et al. (2012) · Annals of the ICRP · doi:10.1016/j.icrp.2012.02.001 · Cited by 1,604
Langendijk, J. A., Lambin, P., De Ruysscher, D., Widder, J., Bos, M., & Verheij, M. (2013) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2013.05.007 · Cited by 549
Violet, J., Jackson, P., Ferdinandus, J., Sandhu, S., Akhurst, T., Iravani, A., Kong, G., Kumar, A. R., Thang, S. P., Eu, P., et al. (2019) · Journal of Nuclear Medicine · doi:10.2967/jnumed.118.219352 · Cited by 504
Kabasakal, L., AbuQbeitah, M., Aygün, A., Yeyin, N., Ocak, M., Demirci, E., & Toklu, T. (2015) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-015-3125-3 · Cited by 208
Peters, S. M. B., Privé, B. M., de Bakker, M., de Lange, F., Jentzen, W., Eek, A., Muselaers, C. H. J., Mehra, N., Witjes, J. A., Gotthardt, M., et al. (2022) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-021-05471-4 · Cited by 88
Metadata
- Authors
- Deasy, J. O., Moiseenko, V., Marks, L., Chao, K. S. C., Nam, J., & Eisbruch, A.
- Venue
- International Journal of Radiation Oncology*Biology*Physics
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 76
- Issue
- 3
- Pages
- S58-S63
- ISSN
- 0360-3016 (ISSN-L)
- OpenAlex
- W2005574374
- Cited by
- 590
- References
- 0
- FWCI
- 21.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Deasy, J. O., Moiseenko, V., Marks, L., Chao, K. S. C., Nam, J., & Eisbruch, A. (2010). Radiotherapy Dose–Volume Effects on Salivary Gland Function. International Journal of Radiation Oncology*Biology*Physics. https://doi.org/10.1016/j.ijrobp.2009.06.090
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