A phase 3 trial of whole brain radiation therapy and stereotactic radiosurgery alone versus WBRT and SRS with temozolomide or erlotinib for non-small cell lung cancer and 1 to 3 brain metastases: Radiation Therapy Oncology Group 0320

Sperduto, Paul W., Wang, Meihua, Robins, H. Ian, Schell, Michael C., Werner-Wasik, Maria, Komaki, Ritsuko, Souhami, Luis, Buyyounouski, Mark K. +7 more·2013·International Journal of Radiation Oncology*Biology*Physics
DOI 10.1016/j.ijrobp.2012.11.042

Cited by (273)

Items 201–273 of 273

  1. [Advances in treatment of brain metastases from primary non-small cell lung cancer].
    Gen Lin, Haipeng Xu, Cheng Huang · 2014 · Europe PMC (PubMed Central)
  2. Brain Metastases from Lung Cancer
    Amol Jitendra Ghia, Ritsuko U Komaki · 2014 · Elsevier eBooks
  3. Diagnostic support of radiosurgery at brain metastases
    Andrey B. Gryazov, Iryna M. Dykan, Nikolay Kolotilov · 2019 · Radiation Diagnostics Radiation Therapy
  4. Cancer Metastasis - Molecular Mechanism and Clinical Therapy
    Yusuf Tutar, Lütfi Tutar · 2022 · IntechOpen eBooks
  5. A retrospective propensity-matched study comparing whole-brain radiotherapy with simultaneous integrated boost to whole-brain radiotherapy alone for brain metastases
    Zheqing Liu, Xiaojing Du, Meiling Deng, Yuanyuan Chen, Shaoxiong Wu · 2025 · BMC Cancer
  6. [Research progress of targeted therapy in non-small cell lung cancer brain metastases].
    Tao Jiang, Caicun Zhou · 2014 · Europe PMC (PubMed Central)
  7. A new brainwave in non-small cell lung cancer: driving targeted therapy to central nervous system metastases
    de Lima Araujo, Luiz Fernando de Oliveira Henrique · 2013 · Translational Cancer Research
  8. RT-based combination therapy for brain metastasis from NSCLC with non-EGFR mutation/ALK gene rearrangement: A network meta-analysis
    Min Wu, Jun Jiang, Xuewen Zhang, Jie Chen, Qiaomei Chang, Rong Chen · 2022 · Frontiers in Oncology
  9. Intracranial management of HER-2 overexpression breast cancer with extensive volume or symptomatic brain metastases
    Juan Li, Junjie Zhen, Ruyu Ai, Mingyao Lai, Hui Wang, Linbo Cai · 2024 · Frontiers in Oncology
  10. Comparative efficacy of osimertinib with and without radiation therapy in EGFR-mutated nonsmall cell lung cancer with brain metastases
    Rafi Aibani, Jennifer N. Collins, Borna Amir-Kabirian, Amir Shahzad Kamran · 2025 · Seminars in Oncology
  11. Brain metastasis: Opportunities for novel therapies
    Zouina Sarfraz, Rupesh R Kotecha, Arun Maharaj, Manmeet Singh Ahluwalia · 2026 · Neurotherapeutics
  12. Considerations on the Management of EGF Receptor-TKIs For Brain Metastases In EGFR -Mutant Lung Carcinoma Patients
    Masato Shingyoji, Toshihiko Iuchi · 2015 · Lung Cancer Management
  13. Advances in palliative radiotherapy of metastatic non-small cell lung cancer
    Rakesh Kapoor, Vijai Simha · 2015 · Translational Cancer Research
  14. Chirurgie et radiothérapie des métastases cérébrales des carcinomes bronchiques non à petites cellules : quand et comment ?
    D. Antoni · 2015 · Revue des Maladies Respiratoires Actualités
  15. An unusual response with long term survival using erlotinib in NSCLC lung with brain metastases
    Madhup Rastogi, Sambit Swarup Nanda, Chandra Prakash, Dinkar Kulshreshtha · 2016 · BMJ Case Reports
  16. The Effect of Tumor Subtype on the Time From Primary Diagnosis to Development of Brain Metastases and Survival in Women With Breast Cancer
    Paul W. Sperduto, Ryan Shanley, Norbert Kased, David Roberge, Samuel T. Chao, Ashley Wayne Jensen, Helen Alice Shih, John P. Kirkpatrick, Laurie E. Gaspar, Minesh P. Mehta · 2012 · International Journal of Radiation Oncology*Biology*Physics
  17. Prise en charge des métastases cérébrales des cancers du poumon
    I. Monnet, G. Rousseau-Bussac, Laurence Jabot, CHRISTOS CHOUAID · 2016 · ONCOLOGIE
  18. Hirnmetastasen solider Tumoren
    Harun Badakhshi · 2017 · Springer eBooks
  19. Role of Stereotactic Radiotherapy in Cranial Metastases of Small Cell Lung Cancer
    Naciye Isık · 2020 · Turkish Journal of Oncology
  20. Applications of Stereotactic Radiosurgery in Neuro-Oncology
    Kunal S. Patel, Paul H. Chapman, Marc R. Bussière, Jay S. Loeffler, Clark C. Chen · 2016 · Elsevier eBooks
  21. Non-small Cell Lung Cancer with Multiple Brain Metastases Treated with Radiosurgery and Erlotinib: A Case Report
    Bilgehan Şahin, Teuta Zoto Mustafayev, Gökhan Aydın, Görkem Güngör, B. Yapici, Banu Atalar, Enis Özyar · 2017 · Cureus
  22. Penetrating the evidence of EGFR and ALK tyrosine kinase inhibitors for non-small cell lung cancer brain metastases
    Christan M. Thomas, Chung‐Shien Lee · 2018 · Journal of Oncology Pharmacy Practice
  23. Improving Patient’s Functioning and Well-Being with Neurorehabilitation
    Quirien Oort, Linda Dirven, MARTIN J.B. TAPHOORN · 2019 · Springer eBooks
  24. Indications for Whole-Brain Radiation Therapy
    Michael Huo, Fábio Ynoe de Moraes, Matthew C. Foote, Mark Blayne Pinkham, Gustavo Nader Marta, John H. Suh · 2020 · Springer eBooks
  25. Central Nervous System Malignancies
    Giuseppe Badalamenti, Massimiliano Cani, Lidia Rita Corsini, Lorena Incorvaia, Alessandro Inno, Stefania Gori · 2021 · UNIPA Springer series
  26. Brain Metastases
    Balamurugan A. Vellayappan, Arjun Sahgal, Kristin Janson Redmond, Lia Moriguchi Halasz, Eric Lin Chang, Simon Shek-Man Lo · 2017 · Medical radiology
  27. Metastatic brain tumours
    Matthias Preusser, Gabriele Schackert, Brigitta G. Baumert · 2017 · Oxford University Press eBooks
  28. Non-Small Cell Lung Cancer Brain Metastasis: The Link between Molecular Mechanisms and Novel Therapeutic Approaches
    Shiva Najjary, Dana A. M. Mustafa, Johan M. Kros · 2022 · IntechOpen eBooks
  29. Reply to V.R. Bhatt et al and M.C. Chamberlain
    James William Welsh, Susan Lynne McGovern, Jeffrey Scott Wefel, Ritsuko K. Komaki, Paul D. Brown, Hendrick Soh · 2013 · Journal of Clinical Oncology
  30. Neurological Complications of Lung Cancer
    Ming Chi, Manmeet Singh Ahluwalia · 2017 · Springer eBooks
  31. Improving patient selection and outcome of stereotactic radiosurgery as a single treatment modality for brain metastases
    J.D. Zindler · 2017
  32. Central Nervous System
    Steve E. Braunstein, Florence Yuen · 2016 · Springer eBooks
  33. Análise dimensional de metástases cerebrais de carcinoma de pulmão do tipo não-pequenas células para otimização da resposta terapêutica à radiocirurgia estereotáxica
    Eliseu Becco Neto · 2022
  34. Whole-Brain Radiotherapy for Brain Metastases: Is the Therapeutic Window Enlarging?
    Nicholas B. Dye, Vinai Gondi, Paul D. Brown, Minesh P. Mehta · 2015 · Elsevier eBooks
  35. Radiation-Refractory Brain Metastases in Patients with Non-Small Cell Lung Cancer
    Clayton M. Spiceland, Kenneth R. Olivier, Aminah Jatoi · 2015 · Journal of Palliative Medicine
  36. Chemotherapie von Hirntumoren bei Erwachsenen
    Patrick Roth, Michael Weller · 2015 · Der Nervenarzt
  37. Welchen Stellenwert hat die Therapie mit Erlotinib im Vergleich zur Strahlentherapie?
    Rolf‐Dieter Kortmann, Clemens Seidel · 2015 · Info Onkologie
  38. In Reply to Robins et al
    Paul W. Sperduto · 2013 · International Journal of Radiation Oncology*Biology*Physics
  39. The role of pre- and post-SRS systemic therapy in patients with NSCLC brain metastases
    Shyamal Patel, Waleed Fouad Mourad, Rajal Patel · 2016 · International Journal of Cancer Therapy and Oncology
  40. Brain Metastases from Non-Small Cell Lung Cancer: Current Evidence in Management Using Tyrosine Kinase Inhibitor and Whole-Brain Radiation Therapy
    Abhinav Binod Chandra, Yiqing Xu · 2015 · Elsevier eBooks
  41. Hirnmetastasen
    Jürgen Dunst, Dirk Rades · 2014 · Der Onkologe
  42. MULTIPLE BRAIN METASTASES
    Gregory M.M. Videtic, Elizabeth Gore, Jeffrey D. Bradley, John Michael Buatti, Isabelle M. Germano, A. Paiman Ghafoori, M. Henderson, Simon Shek-Man Lo, Stephen Lutz, Gregory J. A. Murad et al. · 2014
  43. Translational Research and Immunotherapy in Lung Cancer
    Jonathan E. Schoenhals, Eric D. Brooks, María Angélica Cortez, Steven Neema Seyedin, Sharareh Niknam, Xiaohong Wang, Alexandra P. Cadena, Xuan Shirley Li, Daniel R. Gomez, Zhongxing X. Liao et al. · 2016 · Springer eBooks
  44. Prise en charge des métastases cérébrales des carcinomes bronchiques
    Jordi Remón, Jihene Lahmar, Frederic G Dhermain, Benjamin Besse · 2016 · Revue des Maladies Respiratoires Actualités
  45. PP01. TARGETING MYC/MYCN BY INHIBITION OF CHECKPOINT KINASE 1 (CHK1) SENSITIZES PAEDIATRIC GLIOBLASTOMA (PGBM) CELLS TO TEMOZOLOMIDE
    Meera Nandhabalan · 2017 · Neuro-Oncology
  46. CONCURRENT WHOLE BRAIN IRRADIATION WITH OR WITHOUT TEMOZOLOMIDE IN TREATMENT OF BRAIN METASTASES FROM BREAST CANCER.
    Mohamed Abdelgawad, Eman I. Ismail, Abbas Mahmoud Sarhan · 2017 · International Journal of Advanced Research
  47. Brain Metastases in Lung Cancer With Targetable Mutations—Reply
    Paul W. Sperduto, Minesh P. Mehta · 2017 · JAMA Oncology
  48. Métastases cérébrales des cancers bronchiques non à petites cellules (CBNPC)
    I. Monnet · 2017 · Revue des Maladies Respiratoires Actualités
  49. Stereotactic Radiosurgery for Multiple Brain Metastases: A Dose-Volume Study
    Tanya Kairn, Somayeh Zolfaghari, Daniel Papworth, M West, D. Schlect, Scott Crowe · 2018 · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany
  50. Metastatic Brain Tumors: To Treat or Not to Treat, and with What?
    Patricia Tai, Kurian Joseph, A. Assouline, Osama Souied, Nelson Leong, Michelle Ferguson, Edward Yu · 2018 · Current Cancer Therapy Reviews
  51. Management of lung cancer brain metastasis: An overview
    Himanshu Srivastava, Preety Negi, Pamela Alice Kingsley, Jaineet Sachdeva · 2017 · Asian Journal of Oncology
  52. Role of Whole-Brain Radiotherapy
    Connor M. Lynch, Jeffrey P. Gross, Vinai Gondi · 2020 · Springer eBooks
  53. Neurocognitive Effects of Brain Metastases and Their Treatment
    Karine A. Al Feghali, Mariana E. Bradshaw, Caroline D. Chung, Jeffrey Scott Wefel · 2020 · Springer eBooks
  54. Dose Tolerances in Brain Metastasis Management
    Giuseppe Caracciolo Minniti, Claudia Scaringi, Barbara Tolu · 2020 · Springer eBooks
  55. 22 Natural History and Management Options of Cerebral Metastases cerebral metastases
    2021 · Thieme Medical Publishers eBooks
  56. Neurological complications of lung cancer
    Leon D. Kaulen, Benjamin Y. Lu, Sarah B. Goldberg, Joachim M. Baehring · 2022 · Elsevier eBooks
  57. Post-Whole Brain Radiation Therapy Systemic Treatment Increases Survival
    2018
  58. Brain Metastases
    Paul W. Sperduto, Laurie E. Gaspar · 2013 · Medical radiology
  59. Brain Metastases
    Antonin Lévy, Frederic G Dhermain · 2014 · Springer eBooks
  60. Brain Metastases
    Harun Badakhshi · 2016 · Springer eBooks
  61. Prophylactic cranial irradiation for stage III non-small cell lung cancer patients treated with curative intent
    Willem J. A. Witlox · 2022
  62. Treatment of Isolated Intracranial Progression of Lung Cancer During Treatment with Systemic Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR-TKIs)
    Amanda Tufman, Kathrin Schrödl, Heike Scheithauer, Thomas Duell, Eva Coppenrath, Rudolf Maria Hube · 2015 · EMJ Respiratory
  63. Radiation Therapy for Brain Metastases
    Dirk Rades, Sabine Bohnet, Steven E. Schild · 2022 · Medical radiology
  64. Data from ATR Inhibitor M6620 (VX-970) Enhances the Effect of Radiation in Non–Small Cell Lung Cancer Brain Metastasis Patient-Derived Xenografts
    Andrew M. Baschnagel, Jacob H. Elnaggar, Haley J. VanBeek, Ashley C. Kromke, Justin H. Skiba, Saakshi Kaushik, Lindsey Abel, Paul A. Clark, Colin A. Longhurst, Kwangok P. Nickel et al. · 2023
  65. Icotinib, an EGFR-TKI, for the treatment of brain metastases in non-small cell lung cancer: a retrospective study
    Qunhui Wang, Hua Zheng, Ying Hu, Baohua Lu, Fanbin Hu, Hongmei Zhang, Baolan Li · 2016 · Oncology and Translational Medicine
  66. Physics of Stereotactic Radiosurgery and Stereotactic Body Radiotherapy
    A Pérez-Andújar, Martina Descovich, Cynthia Chuang · 2023 · Springer eBooks
  67. Unraveling the effects of radiotherapy on the blood-brain barrier: Fact or fiction?
    Rupesh R Kotecha, Minesh P. Mehta · 2025 · Neuro-Oncology
  68. Multimodality treatment approach in a patient with EGFR-mutated NSCLC and leptomeningeal metastases: A case report and literature review
    Long-Hai Shen, Xinxin Yan · 2025 · Medicine
  69. Tailored radiotherapy for brain metastases improves precision and outcomes
    Jing Bao, Xuxu Xu, Shepeng Wei, Zhenjiang Pan · 2025 · Discover Oncology
  70. Évaluation et caractérisation de l'efficacité thérapeutique de nanoparticules multifonctionnelles pour de la thérapie photodynamique interstitielle appliquée au glioblastome
    Mickaël Gries · 2021
  71. Safety and efficacy of delivering systemic treatments concomitantly with whole-brain radiotherapy: a prospective, observational, single-institution study
    Maria Protopapa, Kalliopi Platoni, Michalis Psarras, Styliani Nikoloudi, Zoi Liakouli, Despoina Alexiou, Christina Armpilia, Christos E. Antypas, Christos Papadimitriou, Vassilis Kouloulias et al. · 2026 · Exploration of Targeted Anti-tumor Therapy
  72. LINACS: a living systematic review of the safety of concurrent stereotactic radiotherapy and novel systemic therapies by the ESTRO/EORTC OligoCare Consortium
    Nora Sundahl, Esmée L. Looman, L. Ollivier, Matteo Bagnalasta, Piet Ost, Matthias Gückenberger, Jeffrey M. Ryckman, Matthew M. Culbert, Geertruida Elsiena Bekkering, Sabrina Reichl · 2026 · Radiotherapy and Oncology
  73. Hirnmetastasen bei pulmonalem Adenokarzinom mit EGFR-Mutation
    Clemens Seidel, Rolf‐Dieter Kortmann · 2014 · Strahlentherapie und Onkologie