The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Paths reunited: Initiation of the classical and lectin pathways of complement activation
Open accessAbstract
Since its isolation almost fifty years ago, considerable progress has been made towards understanding the structural organisation and mode of action of C1, the initiating complex of the classical pathway of complement activation. Nevertheless, knowledge is still incomplete, especially with regard to the interactions between subcomponents, C1q, C1r and C1s, that trigger activation. Recent studies have provided new insights into these interactions, and have revealed unexpected parallels with initiating complexes of the lectin pathway of complement: MBL-MASP and ficolin-MASP. Here, we develop and expand these concepts and delineate their implications towards the key aspects of complement activation via the classical and lectin pathways.
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Cites
Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
Botto, M., Dell' Agnola, C., Bygrave, A. E., Thompson, E. M., Cook, H. T., Petry, F., Loos, M., Pandolfi, P. P., & Walport, M. J. (1998) · Nature Genetics · doi:10.1038/ng0598-56 · Cited by 1,434
The complement system in regulation of adaptive immunity
Carroll, M. C. (2004) · Nature Immunology · doi:10.1038/ni1113 · Cited by 1,035
Complement: a unique innate immune sensor for danger signals
GASQUE, P. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.06.011 · Cited by 552
Budayova‐Spano, M., Lacroix, M., Thielens, N. M., Arlaud, G. J., Fontecilla‐Camps, J. C., & Gaboriaud, C. (2002) · The EMBO Journal · doi:10.1093/emboj/21.3.231 · Cited by 111
Cited by
Complement: a key system for immune surveillance and homeostasis
Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654
Complement activation, regulation, and molecular basis for complement‐related diseases
Bajic, G., Degn, S. E., Thiel, S., & Andersen, G. R. (2015) · The EMBO Journal · doi:10.15252/embj.201591881 · Cited by 374
Deciphering the Fine Details of C1 Assembly and Activation Mechanisms: “Mission Impossible�
Gaboriaud, C., Ling, W. L., Thielens, N. M., Bally, I., & Rossi, V. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00565 · Cited by 64
The complement system and its role in the pathogenesis of periodontitis: current concepts
Damgaard, C., Holmstrup, P., Van Dyke, T. E., & Nielsen, C. H. (2015) · Journal of Periodontal Research · doi:10.1111/jre.12209 · Cited by 63
Metadata
- Authors
- Wallis, R., Mitchell, D. A., Schmid, R., Schwaeble, W. J., & Keeble, A. H.
- Venue
- Immunobiology
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 215
- Issue
- 1
- Pages
- 1-11
- ISSN
- 0171-2985 (ISSN-L)
- OpenAlex
- W1963858490
- Cited by
- 169
- References
- 4
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Wallis, R., Mitchell, D. A., Schmid, R., Schwaeble, W. J., & Keeble, A. H. (2010). Paths reunited: Initiation of the classical and lectin pathways of complement activation. Immunobiology. https://doi.org/10.1016/j.imbio.2009.08.006
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