Mycobacteria-induced anaemia revisited: A molecular approach reveals the involvement of NRAMP1 and lipocalin-2, but not of hepcidin
Open accessAbstract
Anaemia is a frequent complication of chronic infectious diseases but the exact mechanisms by which it develops remain to be clarified. In the present work, we used a mouse model of mycobacterial infection to study molecular alterations of iron metabolism induced by infection. We show that four weeks after infection with Mycobacterium avium BALB/c mice exhibited a moderate anaemia, which was not accompanied by an increase on hepatic hepcidin mRNA expression. Instead, infected mice presented increased mRNA expression of ferroportin (Slc40a1), ceruloplasmin (Cp), hemopexin (Hpx), heme-oxygenase-1 (Hmox1) and lipocalin-2 (Lcn2). Both the anaemia and the mRNA expression changes of iron-related genes were largely absent in C.D2 mice which bear a functional allele of the Nramp1 gene. Data presented in this work suggest that anaemia due to a chronic mycobacterial infection may develop in the absence of elevated hepcidin expression, is influenced by Nramp1 and may involve lipocalin-2.
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In systemic M. avium infection, alterations of iron traffic were paralleled by increased expression of ferroportin whereas hepcidin formation in the liver remained unchanged.
“This goes along with the observation in systemic M. avium infection demonstrating that alterations of iron traffic were paralleled by increased expression of ferroportin whereas hepcidin formation in the liver remained unchanged (200).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [200]
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References 50 · Cited by 31
- Authors
- Rodrigues, P. N., Gomes, S. S., Neves, J. V., Gomes-Pereira, S., Correia-Neves, M., Nunes-Alves, C., Stolte, J., Sanchez, M., Appelberg, R., Muckenthaler, M. U., & Gomes, M. S.
- Affiliations
- Universidade do Porto (PT)
- University of Minho (PT)
- European Molecular Biology Laboratory (DE)
- University Hospital Heidelberg (DE)
- Corresponding author
- Rodrigues, Pedro N.
- ORCID
- Venue
- Immunobiology
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 216
- Issue
- 10
- Pages
- 1127-1134
- ISSN
- 0171-2985 (ISSN-L)
- OpenAlex
- W2056902763
- Cited by
- 31
- References
- 50
- Citations by year
- 2026: 2 · 2023: 3 · 2021: 2 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 1
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Immunobiology (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- RepositóriUM (Universidade do Minho) (submittedVersion, other-oa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- mycobacterial infection, anemia of chronic disease, iron metabolism, NRAMP1, neutrophil gelatinase-associated lipocalin, hepcidin, ferroportin, ceruloplasmin, hemopexin, heme oxygenase-1, Mycobacterium avium
- MeSH terms
- Natural Resistance-associated Macrophage Protein 1, Anemia, Animals, Disease Models, Animal, Gene Expression Regulation, Iron, Liver, Mice, Inbred BALB C, Mycobacterium avium, RNA, Messenger, Tuberculosis, Gene Expression Profiling, Antimicrobial Cationic Peptides, Cation Transport Proteins, Mice, Metabolic Networks and Pathways, Lipocalins, Hepcidins
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