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Cited by 56Cardiac Fibrosis and RemodelingViral Infections and Immunology ResearchAtherosclerosis and Cardiovascular Diseases

Macrophage diversity in cardiac inflammation: A review

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Barin, Jobert G., Rose, Noel R., Čiháková, Daniela·2012·Immunobiology
DOI 10.1016/j.imbio.2011.06.009PMC PMC4292796
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Abstract

Cardiac inflammatory disease represents a significant public health burden, and interesting questions of immunopathologic science and clinical inquiry. Novel insights into the diverse programming and functions within the macrophage lineages in recent years have yielded a view of these cells as dynamic effectors and regulators of immunity, host defense, and inflammatory disease. In this review, we examine and discuss recent investigations into the complex participation of mononuclear phagocytic cells in the pathology of animal models of myocarditis.

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  • In preclinical animal models for myocarditis, monocytes and macrophages were predominant populations in heart infiltrates.

    “in preclinical animal models for myocarditis, monocytes and macrophages were predominant populations in the heart infiltrates”

    From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [115]

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Authors
Barin, J. G., Rose, N. R., & Čiháková, D.
Affiliations
Johns Hopkins University (US)
Corresponding author
Čiháková, Daniela
ORCID
Čiháková, Daniela
Venue
Immunobiology
Publisher
Elsevier BV
Published
2012-05
Volume
217
Issue
5
Pages
468-475
ISSN
0171-2985 (ISSN-L)
DOI
10.1016/j.imbio.2011.06.009
PMC
PMC4292796
OpenAlex
W2013349987
Cited by
56
References
118
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 1 · 2013: 4 · 2012: 6
FWCI
0.59
Type
journal article
Language
en
Open access
Licence
Locations
  • Immunobiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (R01HL067290, R01HL113008, R01 HL67290, R01HL070729, R01 HL 70729)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords
macrophage heterogeneity, cardiac inflammation, myocarditis, mononuclear phagocytes, macrophage polarization, immunopathology, host defense
MeSH terms
Animals, Autoimmune Diseases, Humans, Macrophages, Monocytes, Myocarditis, Neoplasms, T-Lymphocytes

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