The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2
Abstract
The mononuclear phagocytes control the body homeostasis through the involvement in resolving tissue injury and further wound healing. Indeed, local tissue microenvironmental changes can significantly influence the functional behavior of monocytes and macrophages. Such microenvironmental changes for example occur in an atherosclerotic plaque during all progression stages. In response to exogenous stimuli, macrophages show a great phenotypic plasticity and heterogeneity. Exposure of monocytes to inflammatory or anti-inflammatory conditions also induces predominant differentiation to proinflammatory (M1) or anti-inflammatory (M2) macrophage subsets and phenotype switch between macrophage subsets. The phenotype transition is accompanied with great changes in the macrophage transcriptome and regulatory networks. Interferon-regulatory factors (IRFs) play a key role in hematopoietic development of monocytes, their differentiation to macrophages, and regulating macrophage maturation, phenotypic polarization, phenotypic switch, and function. Of 9 IRFs, at least 3 (IRF-1, IRF-5, and IRF-8) are involved in the commitment of proinflammatory M1 whereas IRF-3 and IRF-4 control M2 polarization. The role of IRF-2 is context-dependent. The IRF impact on macrophage phenotype plasticity and heterogeneity is complex and involves activating and repressive function in triggering transcription of target genes.
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“IRF-5 is critically involved in M1- macrophage polarization (42)”
From mRNA vaccine with unmodified uridine induces robust type I interferon-dependent anti-tumor immunity in a melanoma model (2022) · cites this paper as [42]
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“which possesses phagocytic capacity, and the ability to secrete reactive nitrogen and oxygen species and pro-inflammatory cytokines such as IL-6, IL-12, IL-23 and TNF-α, which in turn promote CD8+ T cell and NK cell cytotoxicity.”
From mRNA vaccine with unmodified uridine induces robust type I interferon-dependent anti-tumor immunity in a melanoma model (2022) · cites this paper as [42]
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1 retracted
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Ishikawa, H., Ma, Z., & Barber, G. N. (2009) · Nature · doi:10.1038/nature08476 · Cited by 2,759
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- Fleetwood, 2007, Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation, J. Immunol., 178, 5245, 10.4049/jimmunol.178.8.5245 · DOI · Paper page
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Macrophage plasticity: signaling pathways, tissue repair, and regeneration
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M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds
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Alternatively activated macrophages; a double-edged sword in allergic asthma
Abdelaziz, M. H., Abdelwahab, S. F., Wan, J., Cai, W., Wang, H., Cheng, J., Kesavan, D. K., Vasudevan, A., Sadek, A., Su, Z., et al. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02251-w · Cited by 289
Macrophage Polarization in the Development and Progression of Ovarian Cancers: An Overview
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“In addition, interferon regulatory factor (IRF)-1, IRF-5, and IRF-8 are correlated with polarization to the M1 phenotype, while IRF3 and IRF-4 polarize cells to the M2 phenotype (48).”
Background
Metadata
- Authors
- Chistiakov, D. A., Myasoedova, V. A., Revin, V. V., Orekhov, A. N., & Bobryshev, Y. V.
- Affiliations
- Federal Medical Research Centre for Psychiatry and Narcology (RU)
- Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences (RU)
- UNSW Sydney (AU)
- Corresponding author
- Bobryshev, Yuri V.
- Venue
- Immunobiology
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 223
- Issue
- 1
- Pages
- 101-111
- ISSN
- 0171-2985 (ISSN-L)
- OpenAlex
- W2764291671
- Cited by
- 311
- References
- 151
- Citations by year
- 2026: 15 · 2025: 37 · 2024: 29 · 2023: 41 · 2022: 58 · 2021: 48 · 2020: 27 · 2019: 40 · 2018: 16
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Russian Science Foundation (#14-15-00112)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
- Keywords
- interferon regulatory factors, macrophage polarization, M1 macrophages, M2 macrophages, macrophage differentiation, monocyte differentiation, macrophage heterogeneity, macrophage plasticity, IRF1, IRF5, IRF8, IRF3, IRF4, IRF2, atherosclerosis, tissue microenvironment, wound healing
- MeSH terms
- Animals, Cell Differentiation, Gene Expression Regulation, Humans, Macrophages, Cytokines, Th1 Cells, Th2 Cells, Interferon Regulatory Factors, Cell Transdifferentiation
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