Epidermal Langerhans cells – changing views on their function in vivo
Abstract
New experimental models and methods have rendered the field of Langerhans cells very lively. An interesting and productive scientific debate as to the functions of Langerhans cells in vivo is currently going on. We have not yet reached the point where the "pros" would weigh out the "cons", or vice versa. There is good evidence for a lack of Langerhans cell function and for down-regulatory Langerhans cell function in some models. On the other hand, there is also evidence for an active immunogenic and tolerogenic role of Langerhans cells. These recent developments will be discussed.
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Langerhans cells are the principal antigen-presenting cells of the epidermis, express CD1a, langerin, and E-cadherin, and contain Birbeck granules.
“LCs, the principal antigen-presenting cells of the epidermis, express CD1a, langerin, and E-cadherin and contain Birbeck granules [32].”
From Host–Candida auris interactions in the skin (2026) · cites this paper as [32]
Cites
Self- and nonself-recognition by C-type lectins on dendritic cells
Geijtenbeek, T. B. H., van Vliet, S. J., Engering, A., 't Hart, B. A., & van Kooyk, Y. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104558 · Cited by 503 · see citing works
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Host–Candida auris interactions in the skin
Thangamani, S., Balakumar, A., Datta, A., Bryak, G., & Lionakis, M. S. (2026) · PLOS Pathogens · doi:10.1371/journal.ppat.1014075 · Cited by 3 · see citing works
- Authors
- Romani, N., Ebner, S., Tripp, C. H., Flacher, V., Koch, F., & Stoitzner, P.
- Affiliations
- Innsbruck Medical University (AT)
- Corresponding author
- Romani, Nikolaus
- Venue
- Immunology Letters
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 106
- Issue
- 2
- Pages
- 119-125
- ISSN
- 0165-2478 (ISSN-L)
- OpenAlex
- W2067929224
- Cited by
- 81
- References
- 1
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 5 · 2015: 1 · 2014: 3 · 2012: 2
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunology Letters (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- Langerhans cells, epidermis, downregulation, skin immunity, antigen presentation
- MeSH terms
- Epidermal Cells, Animals, Epidermis, Humans, Immune Tolerance, Langerhans Cells, Models, Immunological
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