Immunosenescence and vaccine failure in the elderly: strategies for improving response
Abstract
The immune system of the elderly is particularly susceptible to infectious diseases and displays reduced response to vaccination. The current vaccines, designed for young and adult individuals, proved less effective and less protective in old people. The world population is rapidly ageing, and consequently preventing infectious diseases in the elderly have become an important public health issue. To this end, it is necessary to develop novel vaccines especially suited to raising protective immunity in the ageing population. Approaches in this direction include high-dose vaccines, booster vaccinations, different immunisation routes, and use of new adjuvants. These approaches, still empirical, must be supported by intensive research to unravel the biological and molecular mechanisms underlying immunosenescence. Only this knowledge would allow us to design approaches to immune rejuvenation and more effective vaccines for protecting the elderly.
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MF59, a squalene-based adjuvant, increases chemokine-dependent recruitment of APCs.
“Another interesting compound is MF59, a squalene-based adjuvant, which increases the chemokine-dependent recruitment of APCs (211).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [211]
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References 126 · Cited by 86
- Authors
- Boraschi, D., & Italiani, P.
- Affiliations
- Institute of Protein Biochemistry (IT)
- Institute of Biomedical Technologies (IT)
- Corresponding author
- Boraschi, Diana
- Venue
- Immunology Letters
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 162
- Issue
- 1
- Pages
- 346-353
- ISSN
- 0165-2478 (ISSN-L)
- OpenAlex
- W1993417334
- Cited by
- 86
- References
- 126
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 13 · 2020: 9 · 2019: 10 · 2018: 9 · 2017: 4 · 2016: 10 · 2015: 3 · 2014: 1
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunology Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- immunosenescence, vaccine failure, older adults, high-dose vaccine, booster vaccination, adjuvants, immune rejuvenation, infectious disease prevention, population aging
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Aging, Humans, Immunity, Vaccination, Vaccines
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