The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
T Cell Receptor Recognition Motifs Govern Immune Escape Patterns in Acute SIV Infection
Open accessAbstract
Escape from adaptive T cell immunity through transmutation of viral antigenic structure is a cardinal feature in the pathogenesis of SIV/HIV infection and a major obstacle to antiretroviral vaccine development. However, the molecular determinants of this phenomenon at the T cell receptor (TCR)-antigen interface are unknown. Here, we show that mutational escape is intimately linked to the structural configuration of constituent TCR clonotypes within virus-specific CD8(+) T cell populations. Analysis of 3416 SIV-specific TCR sequences revealed that polyclonal T cell populations characterized by highly conserved TCRB CDR3 motifs were rendered ineffectual by single residue mutations in the cognate viral epitope. Conversely, diverse clonotypic repertoires without discernible motifs were not associated with viral escape. Thus, fundamental differences in the mode of antigen engagement direct the pattern of adaptive viral evolution. These findings have profound implications for the development of vaccines that elicit T cell immunity to combat pathogens with unstable genomes.
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Self-citationA very high level of crossreactivity is an essential feature of the T-cell receptor
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HIV evolution: CTL escape mutation and reversion after transmission
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Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever
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Self-citationTHE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION
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Utzschneider, D. T., Charmoy, M., Chennupati, V., Pousse, L., Ferreira, D. P., Calderon-Copete, S., Danilo, M., Alfei, F., Hofmann, M., Wieland, D., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.07.021 · Cited by 1,085
CD8+ T cell efficacy in vaccination and disease
Appay, V., Douek, D. C., & Price, D. A. (2008) · Nature Medicine · doi:10.1038/nm.f.1774 · Cited by 393
Self-citationImproved Survival with T Cell Clonotype Stability After Anti–CTLA-4 Treatment in Cancer Patients
Cha, E., Klinger, M., Hou, Y., Cummings, C., Ribas, A., Faham, M., & Fong, L. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008211 · Cited by 383
The molecular basis for public T-cell responses?
Venturi, V., Price, D. A., Douek, D. C., & Davenport, M. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2260 · Cited by 342
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Metadata
- Authors
- Price, D. A., West, S. M., Betts, M. R., Ruff, L. E., Brenchley, J. M., Ambrozak, D. R., Edghill-Smith, Y., Kuroda, M. J., Bogdan, D., Kunstman, K., Letvin, N. L., Franchini, G., Wolinsky, S. M., Koup, R. A., & Douek, D. C.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2004-12
- Volume
- 21
- Issue
- 6
- Pages
- 793-803
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1986248194
- Cited by
- 272
- References
- 46
- FWCI
- 6.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Price, D. A., West, S. M., Betts, M. R., Ruff, L. E., Brenchley, J. M., Ambrozak, D. R., Edghill-Smith, Y., Kuroda, M. J., Bogdan, D., Kunstman, K., Letvin, N. L., Franchini, G., Wolinsky, S. M., Koup, R. A., & Douek, D. C. (2004). T Cell Receptor Recognition Motifs Govern Immune Escape Patterns in Acute SIV Infection. Immunity. https://doi.org/10.1016/j.immuni.2004.10.010
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
