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Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes.

Schmid, Dorothee, Pypaert, Marc, Münz, Christian·2007·Immunity
DOI 10.1016/j.immuni.2006.10.018
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Abstract

Major histocompatibility complex (MHC) class II molecules present products of lysosomal proteolysis to CD4(+) T cells. Although extracellular antigen uptake is considered to be the main source of MHC class II ligands, a few intracellular antigens have been described to gain access to MHC class II loading after macroautophagy. However, the general relevance and efficacy of this pathway is unknown. Here we demonstrated constitutive autophagosome formation in MHC class II-positive cells, including dendritic, B, and epithelial cells. The autophagosomes continuously fuse with multivesicular MHC class II-loading compartments. This pathway was of functional relevance, because targeting of the influenza matrix protein 1 to autophagosomes via fusion to the autophagosome-associated protein Atg8/LC3 led to strongly enhanced MHC class II presentation to CD4(+) T cell clones. We suggest that macroautophagy constitutively and efficiently delivers cytosolic proteins for MHC class II presentation and can be harnessed for improved helper T cell stimulation.

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Research works printed but not linked: 45

  1. Appay, 2002, Characterization of CD4+ CTLs ex vivo, J. Immunol., 168, 5954, 10.4049/jimmunol.168.11.5954 · DOI
  2. Banchereau, 1998, Dendritic cells and the control of immunity, Nature, 392, 245, 10.1038/32588 · DOI
  3. Bevan, 2004, Helping the CD8+ T-cell response, Nat. Rev. Immunol., 4, 595, 10.1038/nri1413 · DOI
  4. Brazil, 1997, Excessive degradation of intracellular protein in macrophages prevents presentation in the context of major histocompatibility complex class II molecules, Eur. J. Immunol., 27, 1506, 10.1002/eji.1830270629 · DOI
  5. Bryant, 2004, Class II MHC peptide loading by the professionals, Curr. Opin. Immunol., 16, 96, 10.1016/j.coi.2003.11.011 · DOI
  6. Chen, 1998, Efficient class II major histocompatibility complex presentation of endogenously synthesized hepatitis C virus core protein by Epstein-Barr virus-transformed B-lymphoblastoid cell lines to CD4+ T cells, J. Virol., 72, 8301, 10.1128/JVI.72.10.8301-8308.1998 · DOI
  7. Chicz, 1993, Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles, J. Exp. Med., 178, 27, 10.1084/jem.178.1.27 · DOI
  8. Codogno, 2005, Autophagy and signaling: their role in cell survival and cell death, Cell Death Differ., 12, 1509, 10.1038/sj.cdd.4401751 · DOI
  9. Cresswell, 2005, Mechanisms of MHC class I-restricted antigen processing and cross-presentation, Immunol. Rev., 207, 145, 10.1111/j.0105-2896.2005.00316.x · DOI
  10. Dengjel, 2005, Autophagy promotes MHC class II presentation of peptides from intracellular source proteins, Proc. Natl. Acad. Sci. USA, 102, 7922, 10.1073/pnas.0501190102 · DOI
  11. Deretic, 2006, Autophagy as an immune defense mechanism, Curr. Opin. Immunol., 18, 375, 10.1016/j.coi.2006.05.019 · DOI
  12. Dongre, 2001, In vivo MHC class II presentation of cytosolic proteins revealed by rapid automated tandem mass spectrometry and functional analyses, Eur. J. Immunol., 31, 1485, 10.1002/1521-4141(200105)31:5<1485::AID-IMMU1485>3.0.CO;2-A · DOI
  13. Dörfel, 2005, Processing and presentation of HLA class I and II epitopes by dendritic cells after transfection with in vitro transcribed MUC1 RNA, Blood, 105, 3199, 10.1182/blood-2004-09-3556 · DOI
  14. Fonteneau, 2001, Generation of high quantities of viral and tumor-specific human CD4+ and CD8+ T-cell clones using peptide pulsed mature dendritic cells, J. Immunol. Methods, 258, 111, 10.1016/S0022-1759(01)00477-X · DOI
  15. Friede, 1996, Natural ligand motifs of closely related HLA-DR4 molecules predict features of rheumatoid arthritis associated peptides, Biochim. Biophys. Acta, 1316, 85, 10.1016/0925-4439(96)00010-5 · DOI
  16. Fu, 2004, Critical role of EBNA1-specific CD4+ T cells in the control of mouse Burkitt lymphoma in vivo, J. Clin. Invest., 114, 542, 10.1172/JCI22053 · DOI
  17. Gueguen, 1996, Presentation of a cytosolic antigen by major histocompatibility complex class II molecules requires a long-lived form of the antigen, Proc. Natl. Acad. Sci. USA, 93, 14692, 10.1073/pnas.93.25.14692 · DOI
  18. Jacobson, 1989, HLA class II-restricted presentation of cytoplasmic measles virus antigens to cytotoxic T cells, J. Virol., 63, 1756, 10.1128/JVI.63.4.1756-1762.1989 · DOI
  19. Jaraquemada, 1990, An endogenous processing pathway in vaccinia virus-infected cells for presentation of cytoplasmic antigens to class II-restricted T cells, J. Exp. Med., 172, 947, 10.1084/jem.172.3.947 · DOI
  20. Jellison, 2005, Cutting edge: MHC class II-restricted killing in vivo during viral infection, J. Immunol., 174, 614, 10.4049/jimmunol.174.2.614 · DOI
  21. Kleijmeer, 1997, Major histocompatibility complex class II compartments in human and mouse B lymphoblasts represent conventional endocytic compartments, J. Cell Biol., 139, 639, 10.1083/jcb.139.3.639 · DOI
  22. Lechler, 1996, The endogenous pathway of MHC class II antigen presentation, Immunol. Rev., 151, 51, 10.1111/j.1600-065X.1996.tb00703.x · DOI
  23. Li, 2005, Compartmentalization of class II antigen presentation: contribution of cytoplasmic and endosomal processing, Immunol. Rev., 207, 206, 10.1111/j.0105-2896.2005.00297.x · DOI
  24. Lich, 2000, Cytoplasmic processing is a prerequisite for presentation of an endogenous antigen by major histocompatibility complex class II proteins, J. Exp. Med., 191, 1513, 10.1084/jem.191.9.1513 · DOI
  25. Liou, 1997, The autophagic and endocytic pathways converge at the nascent autophagic vacuoles, J. Cell Biol., 136, 61, 10.1083/jcb.136.1.61 · DOI
  26. Majeski, 2004, Mechanisms of chaperone-mediated autophagy, Int. J. Biochem. Cell Biol., 36, 2435, 10.1016/j.biocel.2004.02.013 · DOI
  27. Mellman, 2001, Dendritic cells: specialized and regulated antigen processing machines, Cell, 106, 255, 10.1016/S0092-8674(01)00449-4 · DOI
  28. Mizushima, 2005, The pleiotropic role of autophagy: from protein metabolism to bactericide, Cell Death Differ., 12, 1535, 10.1038/sj.cdd.4401728 · DOI
  29. Mizushima, 2004, In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker, Mol. Biol. Cell, 15, 1101, 10.1091/mbc.E03-09-0704 · DOI · Paper page
  30. Muntasell, 2004, Dissection of the HLA-DR4 peptide repertoire in endocrine epithelial cells: strong influence of invariant chain and HLA-DM expression on the nature of ligands, J. Immunol., 173, 1085, 10.4049/jimmunol.173.2.1085 · DOI
  31. Paludan, 2002, EBNA1 specific CD4+ Th1 cells kill Burkitt's lymphoma cells, J. Immunol., 169, 1593, 10.4049/jimmunol.169.3.1593 · DOI
  32. Qi, 2000, Tumor cells present MHC class II-restricted nuclear and mitochondrial antigens and are the predominant antigen presenting cells in vivo, J. Immunol., 165, 5451, 10.4049/jimmunol.165.10.5451 · DOI · Paper page
  33. Reith, 2001, The bare lymphocyte syndrome and the regulation of MHC expression, Annu. Rev. Immunol., 19, 331, 10.1146/annurev.immunol.19.1.331 · DOI
  34. Schmid, 2005, Immune surveillance of intracellular pathogens via autophagy, Cell Death Differ., 12, 1519, 10.1038/sj.cdd.4401727 · DOI
  35. Shintani, 2004, Autophagy in health and disease: a double-edged sword, Science, 306, 990, 10.1126/science.1099993 · DOI
  36. Sparks-Thissen, 2004, An optimized CD4 T-cell response can control productive and latent gammaherpesvirus infection, J. Virol., 78, 6827, 10.1128/JVI.78.13.6827-6835.2004 · DOI
  37. Steinman, 2002, Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance, Proc. Natl. Acad. Sci. USA, 99, 351, 10.1073/pnas.231606698 · DOI
  38. Steinman, 2003, Tolerogenic dendritic cells, Annu. Rev. Immunol., 21, 685, 10.1146/annurev.immunol.21.120601.141040 · DOI
  39. Trombetta, 2005, Cell biology of antigen processing in vitro and in vivo, Annu. Rev. Immunol., 23, 975, 10.1146/annurev.immunol.22.012703.104538 · DOI
  40. Yawalkar, 2001, A comparative study of the expression of cytotoxic proteins in allergic contact dermatitis and psoriasis: spongiotic skin lesions in allergic contact dermatitis are highly infiltrated by T cells expressing perforin and granzyme B, Am. J. Pathol., 158, 803, 10.1016/S0002-9440(10)64027-8 · DOI
  41. Yewdell, 2003, Making sense of mass destruction: quantitating MHC class I antigen presentation, Nat. Rev. Immunol., 3, 952, 10.1038/nri1250 · DOI
  42. Yorimitsu, 2005, Autophagy: molecular machinery for self-eating, Cell Death Differ., 12, 1542, 10.1038/sj.cdd.4401765 · DOI
  43. Zeng, 2001, CD4+ T cell recognition of MHC class II-restricted epitopes from NY-ESO-1 presented by a prevalent HLA DP4 allele: association with NY-ESO-1 antibody production, Proc. Natl. Acad. Sci. USA, 98, 3964, 10.1073/pnas.061507398 · DOI
  44. Zhou, 2005, Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens, Immunity, 22, 571, 10.1016/j.immuni.2005.03.009 · DOI
  45. Zwart, 2005, Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape, Immunity, 22, 221, 10.1016/j.immuni.2005.01.006 · DOI

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Metadata

Authors
Schmid, D., Pypaert, M., & Münz, C.
Venue
Immunity
Publisher
Elsevier BV
Published
2007-01
Volume
26
Issue
1
Pages
79-92
ISSN
1074-7613
DOI
10.1016/j.immuni.2006.10.018
Cited by
577
References
5
Language
en
Licence

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