Revving the Engine: Signal Transduction Fuels T Cell Activation
Open accessAbstract
For initiation of an immune response, resting T cells must reprogram their metabolism. Continuing the "From the Field" series (see Editorial [2007] 26, 131), Jones and Thompson draw attention to the importance of metabolism during T cell activation and consider how this process is regulated by receptor-mediated signal transduction.
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Metabolism is centrally important in regulating T cell function.
“there has been an increasing understanding of the central importance of metabolism in regulating T cell function [5, 106, 107].”
From Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function (2013) · cites this paper as [5]
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References 28 · Cited by 349
- Authors
- Jones, R. G., & Thompson, C. B.
- Affiliations
- Abramson Cancer Center (US)
- Corresponding author
- Thompson, Craig B.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 27
- Issue
- 2
- Pages
- 173-178
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2061610085
- Cited by
- 349
- References
- 28
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 11 · 2023: 12 · 2022: 20 · 2021: 22 · 2020: 25 · 2019: 21 · 2018: 19 · 2017: 10 · 2016: 13 · 2015: 20 · 2014: 30 · 2013: 29 · 2012: 41
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- T cell activation, signal transduction, T cell metabolism, metabolic reprogramming, receptor signaling, immune response initiation
- MeSH terms
- Animals, Glycolysis, Humans, Lymphocyte Activation, Mitochondria, T-Lymphocytes, Protein Biosynthesis, Signal Transduction
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