The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Tumor Necrosis Factor Signaling Mediates Resistance to Mycobacteria by Inhibiting Bacterial Growth and Macrophage Death
Open accessAbstract
Summary Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by directing formation of granulomas, organized aggregates of macrophages and other immune cells. Loss of TNF signaling causes progression of tuberculosis in humans and the increased mortality of Mycobacterium tuberculosis-infected mice is associated with disorganized and necrotic granulomas, though the precise roles of TNF signaling in the stages of pathogenesis preceding this endpoint remain undefined. We monitor transparent Mycobacterium marinum-infected zebrafish live to conduct a stepwise dissection of the effects of TNF signaling in mycobacterial pathogenesis. We find that loss of TNF signaling causes increased mortality even when only innate immunity is operant. In the absence of TNF intracellular bacterial growth and granuloma formation are accelerated followed by necrotic death of overladen macrophages and granuloma breakdown. Thus TNF is not required for tuberculous granuloma formation, but maintains granuloma integrity indirectly by restricting mycobacterial growth within macrophages and preventing their necrosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Liu, P. T., Stenger, S., Li, H., Wenzel, L., Tan, B. H., Krutzik, S. R., Ochoa, M. T., Schauber, J., Wu, K., Meinken, C., et al. (2006) · Science · doi:10.1126/science.1123933 · Cited by 3,924
Hsu, T., Hingley-Wilson, S. M., Chen, B., Chen, M., Dai, A. Z., Morin, P. M., Marks, C. B., Padiyar, J., Goulding, C., Gingery, M., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1635213100 · Cited by 731
Herbomel, P., Thisse, B., & Thisse, C. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0393 · Cited by 574
Parichy, D. M., Ransom, D. G., Paw, B., Zon, L. I., & Johnson, S. L. (2000) · Development · doi:10.1242/dev.127.14.3031 · Cited by 384
O'Sullivan, M. P., O'Leary, S., Kelly, D. M., & Keane, J. (2007) · Infection and Immunity · doi:10.1128/iai.01107-06 · Cited by 74
Cited by
Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections
Tobin, D. M., Roca, F. J., Oh, S. F., McFarland, R., Vickery, T. W., Ray, J. P., Ko, D. C., Zou, Y., Bang, N. D., Chau, T. T. H., et al. (2012) · Cell · doi:10.1016/j.cell.2011.12.023 · Cited by 580
Self-citationTuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium
Volkman, H. E., Pozos, T. C., Zheng, J., Davis, J. M., Rawls, J. F., & Ramakrishnan, L. (2010) · Science · doi:10.1126/science.1179663 · Cited by 448
Self-citationInflammatory signaling in human tuberculosis granulomas is spatially organized
Marakalala, M. J., Raju, R. M., Sharma, K., Zhang, Y. J., Eugenin, E. A., Prideaux, B., Daudelin, I. B., Chen, P.-Y., Booty, M. G., Kim, J. H., et al. (2016) · Nature Medicine · doi:10.1038/nm.4073 · Cited by 308
Yang, C.-T., Cambier, C. J., Davis, J. M., Hall, C. J., Crosier, P. S., & Ramakrishnan, L. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.07.009 · Cited by 293
Self-citationRoca, F. J., Whitworth, L. J., Redmond, S., Jones, A. A., & Ramakrishnan, L. (2019) · Cell · doi:10.1016/j.cell.2019.08.004 · Cited by 233
Self-citation
Metadata
- Authors
- Clay, H., Volkman, H. E., & Ramakrishnan, L.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 29
- Issue
- 2
- Pages
- 283-294
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2100088019
- Cited by
- 383
- References
- 5
- FWCI
- 12.23
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Tumor Necrosis Factor Signaling Mediates Resistance to Mycobacteria by Inhibiting Bacterial Growth and Macrophage Death. https://app.cochat.ai/papers/10.1016/j.immuni.2008.06.011
- The paper
- Clay, H., Volkman, H. E., & Ramakrishnan, L. (2008). Tumor Necrosis Factor Signaling Mediates Resistance to Mycobacteria by Inhibiting Bacterial Growth and Macrophage Death. Immunity. https://doi.org/10.1016/j.immuni.2008.06.011
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
